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Anti-APC11 [CRQ1.1]

Invented by Dr Jonathon Pines at Gurdon Institute

Info

Catalogue Number 152734
Applications WB
Antigen/Gene or Protein Targets APC11, Cyclosome subunit 11
Reactivity Human
Relevance The anti-APC11 antibody, clone CRQ1.1 has been raised in mouse against the C-terminal portion of APC11 and it reacts with human. APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo.
Host Mouse
Immunogen C-terminal peptide - CRQEWKFKE
Subclass IgG2a
Positive Control Hela cells
Research Area Cell Cycle, Protein Degradation

References: 2 entries

Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.

Europe PMC ID: 23288039


Add a reference

References: 2 entries

Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.

Europe PMC ID: 23288039


Add a reference

References: 2 entries

Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.

Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.


Add a reference


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