Anti-APC11 [CRQ1.1]
Invented by Dr Jonathon Pines from Gurdon Institute
Invented at University of Cambridge
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152734 |
| Applications | WB |
| Antigen/Gene or Protein Targets | APC11, Cyclosome subunit 11 |
| Reactivity | Human |
| Relevance | The anti-APC11 antibody, clone CRQ1.1 has been raised in mouse against the C-terminal portion of APC11 and it reacts with human. APC11 is the catalytic subunit of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. Specifically, Apc11 acts as an E3 enzyme and is responsible for recruiting E2s to the APC and for mediating the subsequent transfer of ubiquitin to APC substrates in vivo. |
| Host | Mouse |
| Immunogen | C-terminal peptide - CRQEWKFKE |
| Positive Control | Hela cells |
| Subclass | IgG2a |
| Research Area | Cell Cycle, Protein Degradation |
References: 2 entries
Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
Europe PMC ID: 23288039
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References: 2 entries
Sedgwick et al. 2013. EMBO J. 32(2):303-14. PMID: 23288039.
Mechanisms controlling the temporal degradation of Nek2A and Kif18A by the APC/C-Cdc20 complex.
Add a reference
