Anti-Leu1, Recombinant [UCH-T2]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152730 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Leu1 (CD5) |
| Reactivity | Human |
| Relevance | Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia. |
| Host | Mouse |
| Immunogen | Thymocytes followed by Sezary T cells. |
| Subclass | IgG2a |
| Research Area | Immunology, Stem Cell Biology |
| Notes |
Recommended for Immunofluorescence and immunostaining of frozen samples and the enrichment of T cell populations by cell sorting or panning. Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. Three different variants available: - Anti-CD5 [UCHT2], Mouse IgG1, Kappa - Anti-CD5 [UCHT2], Mouse IgG1, Kappa, containing key point mutations that abrogate binding to Fc gamma receptors. - Anti-CD5 [UCHT2], Rabbit IgG, Kappa |
References: 2 entries
Original hybridoma first published in: Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Europe PMC ID: 17878328
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References: 2 entries
Original hybridoma first published in: Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Add a reference
