Anti-Leu1, Recombinant [UCH-T2]
Invented by Prof Peter Beverley at Imperial College
- Datasheet
- References (2)
- Inventor Info
Info
| Catalogue Number | 152730 |
| Applications | IHC IF WB |
| Antigen/Gene or Protein Targets | Leu1 (CD5) |
| Reactivity | Human |
| Relevance | Leu-1 is a surface glycoprotein present on peripheral T cells (>95%) and B-cell chronic lymphocytic leukaemia cells that binds CD72. Absence of the Leu-1 marker on childhood ALL cells is associated with a more favourable prognosis. UCH-T2 is useful for detection of T cells in peripheral blood and lymph nodes and categorisation of T cell lymphomas and B cell chronic lymphocytic leukaemia. |
| Host | Mouse |
| Immunogen | Thymocytes followed by Sezary T cells. |
| Subclass | IgG2a |
| Research Area | Immunology, Stem Cell Biology |
| Notes |
Recommended for Immunofluorescence and immunostaining of frozen samples and the enrichment of T cell populations by cell sorting or panning. Recombinant monoclonal antibody produced from the original monoclonal. Manufactured using Absolute Antibody’s Recombinant Platform with variable regions (i.e. specificity) from the hybridoma. |
References: 2 entries
Original hybridoma first published in: Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Europe PMC ID: 17878328
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References: 2 entries
Original hybridoma first published in: Gary-Gouy et al. 2007. J Immunol. 179(7):4335-44. PMID: 17878328.
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
Add a reference
