Anti-IgM [UCH-B1]
Invented by Prof Peter Beverley from Imperial College
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (10)
- Inventor Info
Info
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| Catalogue Number | 152696 |
| Applications | FACS IHC IF IP Fn |
| Antigen/Gene or Protein Targets | Prolymphocytic leukaemia B cells Leukemia |
| Synonyms | B-lymphocytes, IgM, B cell antigen receptor (BCR) |
| Reactivity | Human |
| Relevance | Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for functional BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM. |
| Host | Mouse |
| Immunogen | Human prolymphocytic leukaemia B cells. |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 85 |
| Myeloma Used | NS0 |
| Recommended Growing Conditions | DMEM + 5% FCS |
| Strain | Balb/c |
| Notes | Antibody does not work on formalin fixed and paraffin embedded tissues. |
| Research Area | Immunology, Stem Cell Biology |
References: 10 entries
Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.
IP
Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.
Europe PMC ID: 7807000
DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.
Structure and function of the B-cell antigen receptor.
Europe PMC ID: 7945925
Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.
FACS
Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.
Europe PMC ID: 2208792
Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.
FACS IF Fn
A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.
Europe PMC ID: 3257923
Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.
Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.
Europe PMC ID: 6202990
Add a reference
References: 10 entries
Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.
IP
Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.
DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.
Structure and function of the B-cell antigen receptor.
Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.
FACS
Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.
Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.
FACS IF Fn
A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.
Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.
Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.
Add a reference
