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Anti-IgM [UCH-B1]

Invented by Prof Peter Beverley at Imperial College

Info

Catalogue Number 152696
Applications FACS IHC IF Fn
Antigen/Gene or Protein Targets Prolymphocytic leukaemia B cells
Synonyms B-lymphocytes, IgM, B cell antigen receptor (BCR)
Reactivity Human
Relevance Human surface membrane bound IgM complexes with a heterodimer of transmembrane proteins of Ig alpha and Ig beta (CD79a and CD79b) to form the B cell antigen receptor (BCR). The BCR complex plays an important role in B cell development and activation. The transmembrane region of mIgM is essential for functional BCR complex assembly. Antibody UCHB1 recognizes surface expressed and soluble human IgM.
Host Mouse
Immunogen Human prolymphocytic leukaemia B cells.
Subclass IgG1
Molecular Weight (kDa) 85
Myeloma Used NS0
Recommended Growing Conditions DMEM + 5% FCS
Strain Balb/c
Notes Antibody does not work on formalin fixed and paraffin embedded tissues.
Research Area Immunology, Stem Cell Biology

References

There are 10 reference entries for this reagent.

View All References

References: 10 entries

Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.

Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.

Europe PMC ID: 7807000

DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.

Structure and function of the B-cell antigen receptor.

Europe PMC ID: 7945925

Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.

Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.

Europe PMC ID: 2208792

Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.

FACS IF Fn

A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.

Europe PMC ID: 3257923

Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.

Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.

Europe PMC ID: 6202990


Add a reference

References: 10 entries

Grupp et al. 1995. J Exp Med. 181(1):161-8. PMID: 7807000.

Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.

DeFranco et al. 1994. Chem Immunol. 59:156-72. PMID: 7945925.

Structure and function of the B-cell antigen receptor.

Smith-Ravin et al. 1990. Clin Exp Immunol. 82(1):181-7. PMID: 2208792.

Characterization of two monoclonal antibodies (UCL4D12 and UCL3D3) that discriminate between human mantle zone and marginal zone B cells.

Armitage et al. 1988. Eur J Immunol. 18(1):67-76. PMID: 3257923.

FACS IF Fn

A new antigen identified by the monoclonal antibody UCHB 1 delivers a costimulatory signal to a subset of human B cells.

Coakham et al. 1984. Lancet. 1(8386):1095-8. PMID: 6202990.

Use of monoclonal antibody panel to identify malignant cells in cerebrospinal fluid.


Add a reference