Anti-UCP1 [Vab12 P4B12*A12]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
- Datasheet
- References (2)
- Inventor Info
Info
![Immunohistochemistry images are showing a strong cytoplasmic positivity of UCP1 in (A) primary colorectal cancer whilst negative staining is observed in (B) normal colon mucosa, using Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/fcce5cbd-5093-48ab-8789-f0acfdfdcbb6.jpg)
![Immunohistochemical analysis of paraffin-embedded human normal pancreas tissue using anti-UCP1 antibody [Vab12 P4B12*A12] showed positive cytoplasmic staining in the Islets of Langerhan. Positive cytoplasmic staining is observed in hibernoma tissue.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/832c6e6b-e8a3-42b9-a019-486cfb5ed405.jpg)
![Immunohistochemical analysis of paraffin-embedded human normal pancreas tissue using anti-UCP1 antibody [Vab12 P4B12*A12] showed positive cytoplasmic staining in the Islets of Langerhan. Positive cytoplasmic staining is observed in hibernoma tissue.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/c9d87f81-0f14-40ad-bbe4-44eb7ba4b398.jpg)
![Immunohistochemistry images are showing a strong cytoplasmic positivity of UCP1 in (A) primary colorectal cancer whilst negative staining is observed in (B) normal colon mucosa, using Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/fcce5cbd-5093-48ab-8789-f0acfdfdcbb6.jpg)
![Immunohistochemical analysis of paraffin-embedded human normal pancreas tissue using anti-UCP1 antibody [Vab12 P4B12*A12] showed positive cytoplasmic staining in the Islets of Langerhan. Positive cytoplasmic staining is observed in hibernoma tissue.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/832c6e6b-e8a3-42b9-a019-486cfb5ed405.jpg)
![Immunohistochemical analysis of paraffin-embedded human normal pancreas tissue using anti-UCP1 antibody [Vab12 P4B12*A12] showed positive cytoplasmic staining in the Islets of Langerhan. Positive cytoplasmic staining is observed in hibernoma tissue.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/c9d87f81-0f14-40ad-bbe4-44eb7ba4b398.jpg)
![Image thumbnail for Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/d0a83e41-5685-480a-b78a-951088666e25.jpg)
![Image thumbnail for Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/b1546e18-c743-4cc0-8fa0-1e829d844673.jpg)
![Image thumbnail for Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/fcce5cbd-5093-48ab-8789-f0acfdfdcbb6.jpg)
![Image thumbnail for Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/832c6e6b-e8a3-42b9-a019-486cfb5ed405.jpg)
![Image thumbnail for Anti-UCP1 [Vab12 P4B12*A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/c9d87f81-0f14-40ad-bbe4-44eb7ba4b398.jpg)
| Catalogue Number | 152686 |
| Applications | ELISA IHC WB |
| Antigen/Gene or Protein Targets | Uncoupling Protein 1 (Mitochondrial, Proton Carrier) (UCP1) |
| Reactivity | Human |
| Relevance | UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide - (10 amino acids) derived from the middle polypeptide region of human UCP1. The exact sequence is proprietary. |
| Positive Control | WB- Jurkat whole cell lysate or overexpression cell lysate; IHC-formalin-fixed, paraffin-embedded human breast cancer |
| Subclass | IgG1 kappa |
| Myeloma Used | P3X63Ag8.653 |
| Research Area | Cancer, Cell Signaling & Signal Transduction, Metabolism |
References: 2 entries
The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.
Europe PMC ID: 30737786
The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis. Alnabulsi et al. 2019. Int J Cancer.
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References: 2 entries
The expression of brown fat-associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis.
The expression of brown fat associated proteins in colorectal cancer and the relationship of uncoupling protein 1 with prognosis. Alnabulsi et al. 2019. Int J Cancer.
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