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Anti-Keratin 1 [LL017]

Info

Catalogue Number 152683
Applications IHC
Antigen/Gene or Protein Targets Keratin 1, Cytokeratin 1
Reactivity Human
Relevance Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 1 is differentiation specific keratin that is one of the predominant keratins in suprabasal keratinocytes in stratified epthelia. Mutations in keratin 1 causes epidermolytic hyperkeratosis. LL017 does not react with any tumour tissue regardless of histological classification.
Host Mouse
Immunogen Synthetic peptide - VSTTYSGVTR
Subclass IgM
Myeloma Used Sp2/0-Ag14
Recommended Growing Conditions DMEM + 5% FCS
Notes Use immunoperoxidase on frozen sections.
Research Area Cell Signaling & Signal Transduction

References

There are 8 reference entries for this reagent.

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References: 8 entries

de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.

IHC

Keratin expression in discoid lupus erythematosus.

Europe PMC ID: 8608342

Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.

IHC

Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.

Europe PMC ID: 7544603

Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.

Keratin expression in basal cell carcinomas.

Europe PMC ID: 1371396

Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.

IHC

Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.

Europe PMC ID: 1721080


Add a reference

References: 8 entries

de Berker et al. 1995. Exp Dermatol. 4(6):350-6. PMID: 8608342.

IHC

Keratin expression in discoid lupus erythematosus.

Leigh et al. 1993. Br J Dermatol. 129(2):110-9. PMID: 7544603.

IHC

Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation.

Markey et al. 1992. Br J Dermatol. 126(2):154-60. PMID: 1371396.

Keratin expression in basal cell carcinomas.

Ishida-Yamamoto et al. 1991. J Invest Dermatol. 97(6):959-68. PMID: 1721080.

IHC

Epidermolysis bullosa simplex (Dowling-Meara type) is a genetic disease characterized by an abnormal keratin-filament network involving keratins K5 and K14.


Add a reference

Inventor Information