Anti-hnRNP-K (isoform1) [N10 P2D3*G2]
Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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![Western blot was performed using anti-hnRNP-K (isoform1) [N10 P2D3*G2] on a Jurkat cell lysate.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/a2d34e04-e8cb-499e-b2b1-9fa654cc6f35.png)
![Immunohistochemistry was performed using anti-hnRNP-K (isoform1) [N10 P2D3*G2] on formalin-fixed, paraffin-embedded tissue sections. Strong nuclear immunostaining was observed in normal skin (A). Nuclear and cytoplasmic immunostaining was observed in breast carcinoma (B). This is in agreement with existing literature as hnRNPK shows aberrant localisation in tumours.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/9496fefd-889c-4dee-924e-09879be13443.jpg)
![Western blot of colon tumour tissue lysates probed with Anti-hnRNP-K (isoform1) [N10 P2D3*G2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/2659a957-e1f7-4786-97de-60a20b0987e6.png)
![Western blot was performed using anti-hnRNP-K (isoform1) [N10 P2D3*G2] on a Jurkat cell lysate.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/a2d34e04-e8cb-499e-b2b1-9fa654cc6f35.png)
![Immunohistochemistry was performed using anti-hnRNP-K (isoform1) [N10 P2D3*G2] on formalin-fixed, paraffin-embedded tissue sections. Strong nuclear immunostaining was observed in normal skin (A). Nuclear and cytoplasmic immunostaining was observed in breast carcinoma (B). This is in agreement with existing literature as hnRNPK shows aberrant localisation in tumours.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/9496fefd-889c-4dee-924e-09879be13443.jpg)
![Western blot of colon tumour tissue lysates probed with Anti-hnRNP-K (isoform1) [N10 P2D3*G2]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/2659a957-e1f7-4786-97de-60a20b0987e6.png)
![Image thumbnail for Anti-hnRNP-K (isoform1) [N10 P2D3*G2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/a2d34e04-e8cb-499e-b2b1-9fa654cc6f35.png)
![Image thumbnail for Anti-hnRNP-K (isoform1) [N10 P2D3*G2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/9496fefd-889c-4dee-924e-09879be13443.jpg)
![Image thumbnail for Anti-hnRNP-K (isoform1) [N10 P2D3*G2]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/2659a957-e1f7-4786-97de-60a20b0987e6.png)
| Catalogue Number | 152670 |
| Applications | IHC WB |
| Antigen/Gene or Protein Targets | Heterogeneous nuclear ribonucleoprotein K – isoform 1, hnRNP-K, hnRNPK |
| Reactivity | Human |
| Relevance | The heterogeneous nuclear ribonucleoprotein K (hnRNP K) is a nucleic acid-binding protein that serves as a docking platform integrating transduction pathways to nucleic acid-directed processes. This protein has recently emerged as an important player in carcinogenesis process. HnRNP K is overexpressed in several human cancers and its aberrant cytoplasmic localization has been associated with a worse prognosis for patients, suggesting that it has a role in cancer progression. |
| Host | Mouse |
| Immunogen | Ovalbumin-conjugated synthetic peptide SVKQYSGKFF (C-terminal sequence) |
| Positive Control | IHC - formalin-fixed, paraffin-embedded colorectal cancer sections; WB - Jurkat cell lysate |
| Subclass | IgG1 kappa |
| Strain | Balb/c |
| Notes | Immunogen peptide sequence is common to mouse, rat, rabbit, chicken, sheep, dog, pig, horse. |
| Research Area | Cell Cycle, Epigenetics & Nuclear Signalling |
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