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Anti-LYPD3 [11F1]

Info

Catalogue Number 152660
Applications FACS IF
Antigen/Gene or Protein Targets Ly6/PLAUR domain-containing protein 3
Reactivity Human
Relevance LYPD3 (Ly6/PLAUR domain-containing protein 3) also known as C4.4A, is a structural homologue of the urokinase receptor, uPAR, which constitutes a well-established prognostic marker in various human cancers. It consists of 346 amino acids and is glycosylphosphatidylinositol (GPI)-anchored, and its extracellular domains are composed of two modules belonging to the Ly6/uPAR/α-neurotoxin (LU) protein domain family. LYPD3 is endogenously expressed in suprabasal cells of squamous epithelia and amnion membrane in human placenta. Currently, LYPD3 has no defined functions but inhibition of tumor cell migration with anti-LYPD3 antibody suggests its role in cell/cell, cell/matrix interaction and tumour invasion and metastasis.
Host Mouse
Immunogen GST-LYPD3 (residues 31 to 326) fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Cancer

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