Anti-CXCL16 [4.4]
Invented at A*STAR Accelerate Technologies Pte Ltd
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![Western blot on lysates prepared from HEK293 FT cells with a plasmid expressing the full length CXCL16 open reading frame. Lane 1: 293FT transfected cell lysate probed with anti-CXCL16 [4.4], Lane 2: 293FT mock cell lysate probed with the same antibody.](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/6826351c-a4b8-41a6-a983-c4af9212ff54.png)
![Immunofluorescence staining of cos7 cells transfected with a plasmid containing a full-length CXCL16 open reading frame (a). 48 hours post transfection cells were fixed with 4% paraformaldehyde permeabilised with 0.1% Triton X-100 and stained using Anti-CXCL16 [4.4] and followed by secondary goat anti-mouse FITC (1:100). Nucleic acid DAPI counterstain is shown in blue. A negative control mock is also shown (b).](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/ab34b015-5292-46a0-b01c-89030c7c034b.png)
![Western blot on lysates prepared from HEK293 FT cells with a plasmid expressing the full length CXCL16 open reading frame. Lane 1: 293FT transfected cell lysate probed with anti-CXCL16 [4.4], Lane 2: 293FT mock cell lysate probed with the same antibody.](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/6826351c-a4b8-41a6-a983-c4af9212ff54.png)
![Immunofluorescence staining of cos7 cells transfected with a plasmid containing a full-length CXCL16 open reading frame (a). 48 hours post transfection cells were fixed with 4% paraformaldehyde permeabilised with 0.1% Triton X-100 and stained using Anti-CXCL16 [4.4] and followed by secondary goat anti-mouse FITC (1:100). Nucleic acid DAPI counterstain is shown in blue. A negative control mock is also shown (b).](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/ab34b015-5292-46a0-b01c-89030c7c034b.png)
![Image thumbnail for Anti-CXCL16 [4.4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/6826351c-a4b8-41a6-a983-c4af9212ff54.png)
![Image thumbnail for Anti-CXCL16 [4.4]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/ab34b015-5292-46a0-b01c-89030c7c034b.png)
| Catalogue Number | 152659 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | C-X-C motif chemokine 16 |
| Reactivity | Human |
| Relevance | CXCL16, a newly discovered CXC chemokine, exists both in a transmembrane and a soluble form. The membrane bound chemokine act as a ligand for CXC chemokine receptor (CXCR) 6 which is expressed by peripheral blood leukocytes. This membrane-bound CXCL16 is expressed in antigen-presenting cells such as monocytes, macrophages, B cells and dendritic cells in the T-cell zone of lymph nodes, whereas the soluble CXCL16 can be produced by constitutive cleavage from the cell membrane. In addition, CXCL16 expression has been associated with a number of human inflammatory diseases including rheumatoid arthritis, interstitial lung diseases, atherosclerosis, coronary artery disease and liver injury. |
| Host | Mouse |
| Immunogen | GST-CXCL16 (143-224aa) fusion protein |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Research Area | Cardiovascular, Immunology |
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