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Anti-SΔ10 [1A9]

Info

Catalogue Number 152652
Applications FACS Fn WB
Antigen/Gene or Protein Targets S protein of the SARS coronavirus
Reactivity Virus
Relevance Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process.
Host Mouse
Immunogen GST-SΔ10 fusion protein
Subclass IgG1
Positive Control SARS-CoV-infected Vero E6 cells
Myeloma Used Sp2/0-Ag14
Research Area Virology

References: 4 entries

Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.

Fn

Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.

Europe PMC ID: 25019613

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Fn

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Europe PMC ID: 16378996


Add a reference

References: 4 entries

Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.

Fn

Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.

Europe PMC ID: 25019613

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Fn

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Europe PMC ID: 16378996


Add a reference

References: 4 entries

Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.

Fn

Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Fn

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.


Add a reference


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