Anti-SΔ10 [1A9]
Invented at A*STAR Accelerate Technologies Pte Ltd
- Datasheet
- References (4)
- Inventor Info
Info
![Western blotting on lysates prepared from SARS-CoV-infected Vero E6 cells (+) using anti-SΔ10 [1A9]. A lysate from mock Vero E6 cells is included as a negative control using anti-SΔ10 [1A9].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/db5906d5-1f70-459d-8046-2fd43db317e8.png)
![FACS analysis on 293T cells infected with recombinant vaccinia virus carrying the S gene using anti-SΔ10 [1A9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/f3a3b3a2-0f65-4e12-9776-cb9ddeac0d7a.png)
![Western blotting on lysates prepared from SARS-CoV-infected Vero E6 cells (+) using anti-SΔ10 [1A9]. A lysate from mock Vero E6 cells is included as a negative control using anti-SΔ10 [1A9].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/db5906d5-1f70-459d-8046-2fd43db317e8.png)
![FACS analysis on 293T cells infected with recombinant vaccinia virus carrying the S gene using anti-SΔ10 [1A9]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/f3a3b3a2-0f65-4e12-9776-cb9ddeac0d7a.png)
![Image thumbnail for Anti-SΔ10 [1A9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/db5906d5-1f70-459d-8046-2fd43db317e8.png)
![Image thumbnail for Anti-SΔ10 [1A9]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/f3a3b3a2-0f65-4e12-9776-cb9ddeac0d7a.png)
| Catalogue Number | 152652 |
| Applications | FACS Fn WB |
| Antigen/Gene or Protein Targets | S protein of the SARS coronavirus |
| Reactivity | Virus |
| Relevance | Severe acute respiratory syndrome coronavirus (SARS-CoV) genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. Both of these processes are critical for virus entry into host cells. The SΔ10 is a fragment containing residues from 1029 to 1129 of the S protein, which is a domain that is crucial for the fusion process. |
| Host | Mouse |
| Immunogen | GST-SΔ10 fusion protein |
| Positive Control | SARS-CoV-infected Vero E6 cells |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Research Area | Virology |
References: 4 entries
Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.
Fn
Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.
Europe PMC ID: 25019613
Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.
Fn
Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.
Europe PMC ID: 16378996
Add a reference
References: 4 entries
Ng et al. 2014. PLoS One. 9(7):e102415. PMID: 25019613.
Fn
Substitution at aspartic acid 1128 in the SARS coronavirus spike glycoprotein mediates escape from a S2 domain-targeting neutralizing monoclonal antibody.
Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.
Fn
Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.
Add a reference
