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Anti-SΔ3 [7G12]

Info

Catalogue Number 152651
Applications IP WB
Antigen/Gene or Protein Targets S protein of the SARS coronavirus
Reactivity Virus
Relevance Monoclonal antibody used to aid understanding the method of SARS membrane fusion and entry.

Background and Research Application
Severe acute respiratory syndrome coronavirus (SARS-CoV) is a species of coronavirus known to infect humans, bats, and certain other mammals. The SARS-related coronavirus is an enveloped, positive-sense, single-stranded RNA virus which enters its host cell by the ACE2 receptor. SARS genome encodes for four structural proteins, namely nucleocaspid (N), spike (S), membrane (M) and envelope (E). The S protein, which forms morphologically characteristic projections on the virion surface, is responsible for binding to cellular receptor and mediating the fusion between viral and cellular membranes. The SΔ3 is a fragment containing residues from 168 to 461 of the S protein. This antibody has use in investigating the mechanism of membrane fusion and virus entry.
Host Mouse
Immunogen GST-SΔ3 fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Notes Production Details
Purified using multi-step affinity chromatography with protein A.

Storage Conditions
Store at -20 degrees frozen. Avoid repeated freeze/thaw cycles.

Points of Interest
This antibody was found to have no viral neutralizing activity (Lip et al., 2006).

Concentration
1mg/ml as standard
Research Area Virology

References

There are 3 reference entries for this reagent.

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References: 3 entries

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.

Europe PMC ID: 16378996


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References: 3 entries

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Lip et al. 2006. J Virol. 80(2):941-50. PMID: 16378996.

Monoclonal antibodies targeting the HR2 domain and the region immediately upstream of the HR2 of the S protein neutralize in vitro infection of severe acute respiratory syndrome coronavirus.


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Inventor Information

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