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Anti-MOAP-1 [4A12]

Info

Catalogue Number 152644
Applications IF WB
Antigen/Gene or Protein Targets Modulator of apoptosis-1
Reactivity Human
Relevance MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells.
Host Mouse
Immunogen GST-MOAP-1 (N-terminal) fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Apoptosis and Programmed Cell Death, Cancer

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