Anti-MOAP-1 [4A12]
Invented at A*STAR Accelerate Technologies Pte Ltd
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![Western blot analysis of lysates prepared from U20S cells transfected with myc-MOAP-1 (+) or vector control (-). Detection was performed using an anti-Myc antibody or anti-MOAP-1 [4A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/cfd9d905-74bc-4068-af2c-65c4def0b061.png)
![Immunofluorescence was performed of U20S cells transfected with myc-MOAP-1 using anti-myc (Red) and anti-MOAP-1 [4A12]. U20S cells transfected with myc-BCL-XL were used as a negative control](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/684ebd6d-4d17-4227-ab0c-0f8cdb99c52e.png)
![Western blot analysis of lysates prepared from U20S cells transfected with myc-MOAP-1 (+) or vector control (-). Detection was performed using an anti-Myc antibody or anti-MOAP-1 [4A12]](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/cfd9d905-74bc-4068-af2c-65c4def0b061.png)
![Immunofluorescence was performed of U20S cells transfected with myc-MOAP-1 using anti-myc (Red) and anti-MOAP-1 [4A12]. U20S cells transfected with myc-BCL-XL were used as a negative control](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/684ebd6d-4d17-4227-ab0c-0f8cdb99c52e.png)
![Image thumbnail for Anti-MOAP-1 [4A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/cfd9d905-74bc-4068-af2c-65c4def0b061.png)
![Image thumbnail for Anti-MOAP-1 [4A12]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/684ebd6d-4d17-4227-ab0c-0f8cdb99c52e.png)
| Catalogue Number | 152644 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Modulator of apoptosis-1 |
| Reactivity | Human |
| Relevance | MOAP-1, also known as MAP-1 (Modulator of apoptosis-1) was initially identified as a Bax-associating protein from a yeast two-hybrid screen using Bax as bait. MOAP-1 is enriched in mitochondria and appears to be an effector for mediating Bax function in mitochondria. Moreover, in supporting the idea that MOAP-1 may be involved in a tumor suppressor axis, MOAP-1 is found to associate with the tumor suppressor RASSF1A to mediate Bax-dependent apoptosis in response to death receptor activation in tumor cells. |
| Host | Mouse |
| Immunogen | GST-MOAP-1 (N-terminal) fusion protein |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Research Area | Apoptosis and Programmed Cell Death, Cancer |
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