Anti-Cathepsin L [4C11]

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Catalogue Number	152642
Applications	IF WB
Antigen/Gene or Protein Targets	Cathepsin L, HCL
Reactivity	Human
Relevance	Cathepsin L is expressed in most cells but in a higher level in cancerous cells. Normal levels of cathepsin L is involved in the regulation of epithelial cell proliferation and differentiation in the skin. It is recognized that many cancer cells secrete cathepsin L to degrade the components of extracellular matrices and basement membranes. This promotes tumor invasion and metastasis. The pro-form of cathepsin L exists as a molecular size of 50kDa. The pro-form could be degraded and secreted out as two smaller forms of cathepsin L. These smaller forms are known as the mature forms. The pro-forms and mature forms are secreted out of the healthy cells. However, there is a significant increase in levels of pro-forms that are secreted out of the cancerous cells. Monoclonal antibodies generated against pro-form of cathepsin L would be useful for diagnostic purposes.
Host	Mouse
Immunogen	GST-HCL fusion protein
Positive Control	Human brain cell lysates, U-138MG cell line
Subclass	IgM
Myeloma Used	Sp2/0-Ag14
Research Area	Adhesion, Cancer, Cell Signaling & Signal Transduction, Neurobiology, Protein Degradation

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	A*STAR Accelerate Technologies Pte Ltd
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