Log in Register
Menu

Anti-Beta3 [7D1]

Info

Catalogue Number 152635
Applications FACS IF WB
Antigen/Gene or Protein Targets Beta3 subunit of high-voltage-gated calcium channel
Reactivity Human
Relevance Voltage-sensitive calcium channels (VSCCs) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-ctx-GVIA) and omegaagatoxin-IVA (omega-aga-IVA). The overall conclusion is that deletion of the beta 3 subunit affects at least three distinct types of High voltage activated Ca2+ channel (L,N and P/Q types), but no single type of channel is solely dependent on beta 3. The beta3 (β3) subunit of high-voltage-gated calcium channels is a peripheral membrane protein that co-purifies with neural N-type calcium channels. Beta3 subunit contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating g protein inhibition and controlling the alpha-1 subunit membrane targeting.
Host Mouse
Immunogen GST-beta3 fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Epigenetics & Nuclear Signalling, Neurobiology

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference

References: 0 entry

There is no reference for this reagent yet, feel free to use the button below to suggest one.

Add a reference


This reagent does not have any reviews at the moment.