Anti-Bam32 [4H9]

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Catalogue Number	152634
Applications	WB
Antigen/Gene or Protein Targets	B lymphocyte-associated adaptor protein
Reactivity	Human
Relevance	B lymphocyte-associated adaptor protein (Bam32) is 32 kDa and is expressed in high levels in the germinal center (GC) of B cells. It consists of a src homology 2 (SH2) domain at the NH2 terminal which binds phospholipase C (PLC) gamma 2 and a pleckstrin homology (PH) domain at the COOH-terminal. Bam32 acts as an adaptor that integrates protein tyrosine kinase (PTK) and phosphatidylinositol 3-kinase (PI3K) necessary for signaling in B cells. Bam32 is recruited to the plasma membrane upon B cell receptor (BCR) ligation. BCR ligation induces colocalization of Bam32 with lipid rafts, clathrin, and actin filaments. BCR internalization which is actin dependent occurs subsequently. Bam32 also play a part in B cell proliferation.
Host	Mouse
Immunogen	GST-Bam32 fusion protein
Positive Control	A20 cell lysate
Subclass	IgG1
Myeloma Used	Sp2/0-Ag14
Research Area	Cell Signaling & Signal Transduction, Immunology

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	A*STAR Accelerate Technologies Pte Ltd
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