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Anti-AIF [3C11]

Info

Catalogue Number 152633
Applications WB
Antigen/Gene or Protein Targets Mammalian apoptosis-inducing factor
Reactivity Human
Relevance Mammalian apoptosis-inducing factor (AIF) has been reported to be mainly found in the inter-membrane space of the mitochondria. After exposure to apoptotic stimuli, AIF is expelled as a soluble protein from the permeabilized mitochondria membrane and translocates to the nucleus, resulting in chromatin condensation and DNA cleavage. AIF mediated apoptosis is caspase-independent. AIF mutants that could not bind to DNA could not mediate cell death.
Host Mouse
Immunogen AIF-His fusion protein
Subclass IgG1
Myeloma Used Sp2/0-Ag14
Research Area Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling, Metabolism

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