Anti-AIF [3C11]
Invented at A*STAR Accelerate Technologies Pte Ltd
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Info
![Western blot was performed on transfected 293T cell lysates using anti-AIF [3C11].](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/b6104a2f-9df1-4eaf-b63b-f31a6f936771.jpg)
![Western blot was performed on transfected 293T cell lysates using anti-AIF [3C11].](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/b6104a2f-9df1-4eaf-b63b-f31a6f936771.jpg)
![Image thumbnail for Anti-AIF [3C11]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/b6104a2f-9df1-4eaf-b63b-f31a6f936771.jpg)
| Catalogue Number | 152633 |
| Applications | WB |
| Antigen/Gene or Protein Targets | Mammalian apoptosis-inducing factor |
| Reactivity | Human |
| Relevance | Mammalian apoptosis-inducing factor (AIF) has been reported to be mainly found in the inter-membrane space of the mitochondria. After exposure to apoptotic stimuli, AIF is expelled as a soluble protein from the permeabilized mitochondria membrane and translocates to the nucleus, resulting in chromatin condensation and DNA cleavage. AIF mediated apoptosis is caspase-independent. AIF mutants that could not bind to DNA could not mediate cell death. |
| Host | Mouse |
| Immunogen | AIF-His fusion protein |
| Subclass | IgG1 |
| Myeloma Used | Sp2/0-Ag14 |
| Research Area | Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, Cell Type or Organelle Marker, Epigenetics & Nuclear Signalling, Metabolism |
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