Anti-NCAM [UJ13A]
Invented by Dr JOHN KEMSHEAD from SHIRE PHARMACEUTICALS
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (7)
- Inventor Info
Info
| Catalogue Number | 152631 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Neural Cell Adhesion Molecule (NCAM; CD56) |
| Synonyms | Neural Cell Adhesion Molecule; NCAM; CD56 Antigen; MSK39 |
| Reactivity | Human |
| Relevance | NCAM, also known as CD56, is a homophillic binding glycoprotein present on a variety of neural cells including neurons, glia, skeletal muscle and natural killer cells. NCAM has been implicated as having a role in cell-cell adhesion, neurite outgrowth, synatptic plasticity, learning and memory and in the development of the nervous system. |
| Host | Mouse |
| Immunogen | 16 week human foetal brain |
| Subclass | IgG1 |
| Molecular Weight (kDa) | 180, 160, 120 |
| Recommended Growing Conditions | DMEM + 5%FCS |
| Notes | Anti-NCAM [UJ13A] is a diagnostic reagent in the characterization of neuro-ectodermally derived tumours and in the identification of metastatic spread to the bone marrow. In addition UJ13A has been used in radio immunoscintigraphy of neuroblastoma and brain tumours and in targeted radiotherapy. |
| Research Area | Adhesion, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Neurobiology, Stem Cell Biology |
References: 7 entries
Patel et al. 1989. Int J Cancer. 44(6):1062-8. PMID: 2558078.
Patel et al. 1989. Br J Cancer. 60(6):861-6. PMID: 2481486.
Monoclonal antibody 3F8 recognises the neural cell adhesion molecule (NCAM) in addition to the ganglioside GD2.
Europe PMC ID: 2481486
Monoclonal antibody UJ13A recognizes the neural cell adhesion molecule (NCAM).
Europe PMC ID: 2558078
Moss et al. 1988. Lung Cancer. 4, 76-78.
Allan et al. 1983. Int J Cancer. 31(5):591-8. PMID: 6852977.
Biological characterization and clinical applications of a monoclonal antibody recognizing an antigen restricted to neuroectodermal tissues.
Europe PMC ID: 6852977
Add a reference
References: 7 entries
Patel et al. 1989. Int J Cancer. 44(6):1062-8. PMID: 2558078.
Patel et al. 1989. Br J Cancer. 60(6):861-6. PMID: 2481486.
Monoclonal antibody 3F8 recognises the neural cell adhesion molecule (NCAM) in addition to the ganglioside GD2.
Monoclonal antibody UJ13A recognizes the neural cell adhesion molecule (NCAM).
Moss et al. 1988. Lung Cancer. 4, 76-78.
Allan et al. 1983. Int J Cancer. 31(5):591-8. PMID: 6852977.
Biological characterization and clinical applications of a monoclonal antibody recognizing an antigen restricted to neuroectodermal tissues.
Add a reference
