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Trauma Haemorrhage, Shock and Resuscitation Rat

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Disease Keywords Haemorrhagic shock
Relevance The Trauma Haemorrhage, Shock and Resuscitation Rat is a preclinical model of massive bleeding and hypovolemic shock, with resuscitation using shed blood and crystalloid to conduct translational and discovery research testing the impact of novel resuscitation strategies upon coagulopathy and organ dysfunction. Hemorrhage is a medical emergency that is frequently encountered by physicians in emergency rooms, operating rooms, and intensive care units. Significant loss of intravascular volume may lead sequentially to hemodynamic instability, decreased tissue perfusion, cellular hypoxia, organ damage, and death.
Production Details Rodent model of fixed-pressure haemorrhagic shock and resuscitation (5 hours)
Conditional No
Mouse Genetic Background/Cross History Wistar rat
Research Area Cardiovascular, Drug Discovery & Development, Genetic Studies Tools

References: 2 entries

Sordi et al. 2015. Mol Med. 21:563-75. PMID: 26101953.

Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.


Add a reference

References: 2 entries

Sordi et al. 2015. Mol Med. 21:563-75. PMID: 26101953.

Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.


Add a reference

References: 2 entries

Sordi et al. 2015. Mol Med. 21:563-75. PMID: 26101953.

Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.


Add a reference


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