Trauma Haemorrhage, Shock and Resuscitation Rat
Invented at Queen Mary University of London
- Datasheet
- References (4)
- Inventor Info
Info
| Disease Keywords | Haemorrhagic shock |
| Relevance | The Trauma Haemorrhage, Shock and Resuscitation Rat is a preclinical model of massive bleeding and hypovolemic shock, with resuscitation using shed blood and crystalloid to conduct translational and discovery research testing the impact of novel resuscitation strategies upon coagulopathy and organ dysfunction. Hemorrhage is a medical emergency that is frequently encountered by physicians in emergency rooms, operating rooms, and intensive care units. Significant loss of intravascular volume may lead sequentially to hemodynamic instability, decreased tissue perfusion, cellular hypoxia, organ damage, and death. |
| Production Details | Rodent model of fixed-pressure haemorrhagic shock and resuscitation (5 hours) |
| Conditional | No |
| Mouse Genetic Background/Cross History | Wistar rat |
| Research Area | Cardiovascular, Drug Discovery & Development, Genetic Studies Tools |
References: 4 entries
Sordi et al. 2015. Mol Med. 21:563-75. PMID: 26101953.
Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock.
Europe PMC ID: 26101953
Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Europe PMC ID: 20553376
Add a reference
References: 4 entries
Sordi et al. 2015. Mol Med. 21:563-75. PMID: 26101953.
Inhibition of IκB Kinase Attenuates the Organ Injury and Dysfunction Associated with Hemorrhagic Shock.
Frith et al. 2010. J Thromb Haemost. 8(9):1919-25. PMID: 20553376.
Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations.
Add a reference
