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Monoclonal Antibodies

Anti-p53 [V5P4H6*B3]

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Image thumbnail for Anti-p53 [V5P4H6*B3]
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Immunohistochemistry using anti-p53 [V5P4H6*B3] on a Zebrafish embryo.
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Image thumbnail for Anti-p53 [V5P4H6*B3]
Catalogue Number 152613
Applications ELISA IHC WB
Antigen/Gene or Protein Targets p53
Reactivity Zebrafish
Relevance p53 acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide KLMVKDEGRS (C-terminal sequence)
Positive Control WB - whole Zebrafish lysate; IHC- Zebrafish embryo
Subclass IgG1 kappa
Research Area Aquaculture, Apoptosis and Programmed Cell Death, Cancer, Cell Cycle, DNA Damage and Repair, Epigenetics & Nuclear Signalling

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