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Anti-ERO1-Like Beta [M37-P5D11]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152603
Applications ELISA IHC WB
Antigen/Gene or Protein Targets ERO1-Like Beta (ERO1LB)
Reactivity Human
Relevance Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.
Host Mouse
Immunogen Peptide – LAPSRGEDDG
Subclass IgG1 kappa
Positive Control WB - Jurkat whole cell lysate, IHC - formalin-fixed, paraffin-embedded human breast cancer
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

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