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Monoclonal Antibodies

Anti-ERO1-Like Beta [M37-P5D11]

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections and showed strong cytoplasmic immunostaining in breast cancer tissue.
Immunohistochemistry images are showing a stronger cytoplasmic staining of ERO1LB in (A) primary colorectal cancer compared to (B) normal colon mucosa using Anti-ERO1LB [M37-P5D11]. IHC was performed on formalin-fixed, paraffin-embedded tissue sections. Antigen retrieval step is required (microwave 10 min @ 950W in 0.01M sodium citrate buffer, pH 6.0).
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Catalogue Number 152603
Applications ELISA IHC WB
Antigen/Gene or Protein Targets ERO1-Like Beta (ERO1LB)
Reactivity Human
Relevance Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the being a source of oxidative stress. Required for the folding of cell, thereby being a source of oxidative stress.
Host Mouse
Immunogen Peptide – LAPSRGEDDG
Positive Control WB - Jurkat whole cell lysate, IHC - formalin-fixed, paraffin-embedded human breast cancer
Subclass IgG1 kappa
Research Area Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Metabolism

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