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Anti-Cytochrome P450 46A1 [N8-P6E4*H8]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152600
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Cytochrome P450, Family 46, Subfamily A, Polypeptide 1 (CYP46A1)
Reactivity Human
Relevance Cytochrome P450 46A1 belongs to the cytochrome P450 family which are a group of monooxygenases. Cytochrome P450 46A1 is involved in the turnover of cholesterol converting it into 24S-hydroxycholesterol and, to a lesser extent, 25-hydroxycholesterol. This protein is expressed in the brain and mRNA has been found to be broadly distributed with higher levels in the gray matter zones and lower levels in white matter areas. It is not detected in fetal brain but its expression increases linearly with age. It localises to the endoplasmic reticulum membrane and the microsome membrane. The unprocessed precursor is 500 amino acids long and has a predicted molecular weight of 56.8KD.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide- PVLCTLRPR (C-terminal sequence)
Subclass IgG1
Positive Control WB - overexpression lysates
Molecular Weight (kDa) 57
Notes This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


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References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


Add a reference

References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


Add a reference


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