LF2 Cell Line
Invented at University of Oxford
- Datasheet
- References (22)
- Inventor Info
Info
| Catalogue Number | 152568 |
| Host | Mouse |
| Tissue | Embryo |
| Relevance | The LF2 mouse embryonic stem cell line is a germ-line competent embryonic stem cell line that inactivates one of its X chromosomes upon retinoic acid treatment. Embryonic stem cells provide a powerful system for the experimental analysis of mammalian development. Their genetic manipulation allows the introduction of defined modifications into the mouse germ-line, whilst in culture they constitute both an assay system for, and a potential source of, embryonic regulatory factors. |
| Conditional | No |
| Research Area | Genetic Studies Tools, Stem Cell Biology |
| Recommended Growing Conditions | Embryonic bodies were formed by growing cells in low adherence dishes in DMEM+FBS for 10 days. |
| Notes | A female Mus musculus, strain 129/Ola embryonic stem cell line. |
| Cellosaurus ID | CVCL_AS05 |
References: 22 entries
Peng et al. 2009. Cell. 139(7):1290-302. PMID: 20064375.
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
Europe PMC ID: 20064375
Marks et al. 2009. Genome Res. 19(8):1361-73. PMID: 19581487.
High-resolution analysis of epigenetic changes associated with X inactivation.
Europe PMC ID: 19581487
Kabuyama et al. 2007. Genes Cells. 12(11):1235-44. PMID: 17986007.
Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Europe PMC ID: 17986007
Bernstein et al. 2006. Mol Cell Biol. 26(7):2560-9. PMID: 16537902.
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Europe PMC ID: 16537902
Hake et al. 2006. J Biol Chem. 281(1):559-68. PMID: 16267050.
Expression patterns and post-translational modifications associated with mammalian histone H3 variants.
Europe PMC ID: 16267050
Atamas et al. 2003. Am J Respir Cell Mol Biol. 29(6):743-9. PMID: 12805086.
Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.
Europe PMC ID: 12805086
Heard et al. 2001. Cell. 107(6):727-38. PMID: 11747809.
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
Europe PMC ID: 11747809
Mermoud et al. 1999. J Cell Biol. 147(7):1399-408. PMID: 10613899.
Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.
Europe PMC ID: 10613899
Keohane et al. 1996. Dev Biol. 180(2):618-30. PMID: 8954732.
X-Inactivation and histone H4 acetylation in embryonic stem cells.
Europe PMC ID: 8954732
Chan et al. 1991. J Exp Med. 173(4):869-79. PMID: 1672545.
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
Europe PMC ID: 1672545
Nichols et al. 1990. Development. 110(4):1341-8. PMID: 2129226.
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity.
Europe PMC ID: 2129226
Add a reference
References: 22 entries
Peng et al. 2009. Cell. 139(7):1290-302. PMID: 20064375.
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
Marks et al. 2009. Genome Res. 19(8):1361-73. PMID: 19581487.
High-resolution analysis of epigenetic changes associated with X inactivation.
Kabuyama et al. 2007. Genes Cells. 12(11):1235-44. PMID: 17986007.
Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.
Bernstein et al. 2006. Mol Cell Biol. 26(7):2560-9. PMID: 16537902.
Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.
Hake et al. 2006. J Biol Chem. 281(1):559-68. PMID: 16267050.
Expression patterns and post-translational modifications associated with mammalian histone H3 variants.
Atamas et al. 2003. Am J Respir Cell Mol Biol. 29(6):743-9. PMID: 12805086.
Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.
Heard et al. 2001. Cell. 107(6):727-38. PMID: 11747809.
Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.
Mermoud et al. 1999. J Cell Biol. 147(7):1399-408. PMID: 10613899.
Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.
Keohane et al. 1996. Dev Biol. 180(2):618-30. PMID: 8954732.
X-Inactivation and histone H4 acetylation in embryonic stem cells.
Chan et al. 1991. J Exp Med. 173(4):869-79. PMID: 1672545.
Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.
Nichols et al. 1990. Development. 110(4):1341-8. PMID: 2129226.
Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity.
Add a reference
