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LF2 Cell Line

Info

Catalogue Number 152568
Host Mouse
Tissue Embryo
Relevance The LF2 mouse embryonic stem cell line is a germ-line competent embryonic stem cell line that inactivates one of its X chromosomes upon retinoic acid treatment. Embryonic stem cells provide a powerful system for the experimental analysis of mammalian development. Their genetic manipulation allows the introduction of defined modifications into the mouse germ-line, whilst in culture they constitute both an assay system for, and a potential source of, embryonic regulatory factors.
Conditional No
Research Area Genetic Studies Tools, Stem Cell Biology
Recommended Growing Conditions Embryonic bodies were formed by growing cells in low adherence dishes in DMEM+FBS for 10 days.
Notes A female Mus musculus, strain 129/Ola embryonic stem cell line.
Cellosaurus ID CVCL_AS05

References: 22 entries

Peng et al. 2009. Cell. 139(7):1290-302. PMID: 20064375.

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Europe PMC ID: 20064375

Marks et al. 2009. Genome Res. 19(8):1361-73. PMID: 19581487.

High-resolution analysis of epigenetic changes associated with X inactivation.

Europe PMC ID: 19581487

Kabuyama et al. 2007. Genes Cells. 12(11):1235-44. PMID: 17986007.

Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.

Europe PMC ID: 17986007

Bernstein et al. 2006. Mol Cell Biol. 26(7):2560-9. PMID: 16537902.

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.

Europe PMC ID: 16537902

Hake et al. 2006. J Biol Chem. 281(1):559-68. PMID: 16267050.

Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

Europe PMC ID: 16267050

Atamas et al. 2003. Am J Respir Cell Mol Biol. 29(6):743-9. PMID: 12805086.

Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.

Europe PMC ID: 12805086

Heard et al. 2001. Cell. 107(6):727-38. PMID: 11747809.

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.

Europe PMC ID: 11747809

Mermoud et al. 1999. J Cell Biol. 147(7):1399-408. PMID: 10613899.

Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.

Europe PMC ID: 10613899

Keohane et al. 1996. Dev Biol. 180(2):618-30. PMID: 8954732.

X-Inactivation and histone H4 acetylation in embryonic stem cells.

Europe PMC ID: 8954732

Chan et al. 1991. J Exp Med. 173(4):869-79. PMID: 1672545.

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

Europe PMC ID: 1672545

Nichols et al. 1990. Development. 110(4):1341-8. PMID: 2129226.

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity.

Europe PMC ID: 2129226


Add a reference

References: 22 entries

Peng et al. 2009. Cell. 139(7):1290-302. PMID: 20064375.

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Europe PMC ID: 20064375

Marks et al. 2009. Genome Res. 19(8):1361-73. PMID: 19581487.

High-resolution analysis of epigenetic changes associated with X inactivation.

Europe PMC ID: 19581487

Kabuyama et al. 2007. Genes Cells. 12(11):1235-44. PMID: 17986007.

Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.

Europe PMC ID: 17986007

Bernstein et al. 2006. Mol Cell Biol. 26(7):2560-9. PMID: 16537902.

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.

Europe PMC ID: 16537902

Hake et al. 2006. J Biol Chem. 281(1):559-68. PMID: 16267050.

Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

Europe PMC ID: 16267050

Atamas et al. 2003. Am J Respir Cell Mol Biol. 29(6):743-9. PMID: 12805086.

Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.

Europe PMC ID: 12805086

Heard et al. 2001. Cell. 107(6):727-38. PMID: 11747809.

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.

Europe PMC ID: 11747809

Mermoud et al. 1999. J Cell Biol. 147(7):1399-408. PMID: 10613899.

Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.

Europe PMC ID: 10613899

Keohane et al. 1996. Dev Biol. 180(2):618-30. PMID: 8954732.

X-Inactivation and histone H4 acetylation in embryonic stem cells.

Europe PMC ID: 8954732

Chan et al. 1991. J Exp Med. 173(4):869-79. PMID: 1672545.

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

Europe PMC ID: 1672545

Nichols et al. 1990. Development. 110(4):1341-8. PMID: 2129226.

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity.

Europe PMC ID: 2129226


Add a reference

References: 22 entries

Peng et al. 2009. Cell. 139(7):1290-302. PMID: 20064375.

Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.

Marks et al. 2009. Genome Res. 19(8):1361-73. PMID: 19581487.

High-resolution analysis of epigenetic changes associated with X inactivation.

Kabuyama et al. 2007. Genes Cells. 12(11):1235-44. PMID: 17986007.

Involvement of selenoprotein P in the regulation of redox balance and myofibroblast viability in idiopathic pulmonary fibrosis.

Bernstein et al. 2006. Mol Cell Biol. 26(7):2560-9. PMID: 16537902.

Mouse polycomb proteins bind differentially to methylated histone H3 and RNA and are enriched in facultative heterochromatin.

Hake et al. 2006. J Biol Chem. 281(1):559-68. PMID: 16267050.

Expression patterns and post-translational modifications associated with mammalian histone H3 variants.

Atamas et al. 2003. Am J Respir Cell Mol Biol. 29(6):743-9. PMID: 12805086.

Pulmonary and activation-regulated chemokine stimulates collagen production in lung fibroblasts.

Heard et al. 2001. Cell. 107(6):727-38. PMID: 11747809.

Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation.

Mermoud et al. 1999. J Cell Biol. 147(7):1399-408. PMID: 10613899.

Histone macroH2A1.2 relocates to the inactive X chromosome after initiation and propagation of X-inactivation.

Keohane et al. 1996. Dev Biol. 180(2):618-30. PMID: 8954732.

X-Inactivation and histone H4 acetylation in embryonic stem cells.

Chan et al. 1991. J Exp Med. 173(4):869-79. PMID: 1672545.

Induction of interferon gamma production by natural killer cell stimulatory factor: characterization of the responder cells and synergy with other inducers.

Nichols et al. 1990. Development. 110(4):1341-8. PMID: 2129226.

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity.


Add a reference


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