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Anti-ADAM28, Polyclonal [28MOCYT]

Invented by Prof Carl Blobel at Hospital For Special Surgery At Weill Cornell Medicine

Info

Catalogue Number 152535
Applications WB
Antigen/Gene or Protein Targets ADAM28
Reactivity Mouse
Relevance ADAM28, also known as eMDCII, MDC-Ls and TECADAM, was first described in lymphocytes, also in Thymic Endothelial Cells (TECADAM), as well as in the epididymus. Later works describe two forms of ADAM28: ADAM28-S and ADAM28-L (short and long forms). The short form is a soluble, alternatively spliced form lacking the transmembrane and cytoplasmic domains. A member of the metalloproteinase family containing disintegrin-like domains (ADAMs) the functions of ADAM28 is still poorly understood. Other ADAMs family members (ADAM10, ADAM17) have been more thoroughly studied and are known to play key roles in inflammation, growth factor maturation and release, and a wide range of other functions. ADAM28 may play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. It may be involved in sperm maturation.
Host Rabbit
Immunogen GST-fusion protein with the cytoplasmic domain of murine ADAM28
Formulation Whole serum
Molecular Weight (kDa) ~100
Notes Suggested dilutions for western blot: 1:500
Research Area Cancer, Cell Signaling & Signal Transduction

References: 1 entry

Howard et al. 2000. Biochem J. 348 Pt 1:21-7. PMID: 10794709.


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References: 1 entry

Howard et al. 2000. Biochem J. 348 Pt 1:21-7. PMID: 10794709.


Add a reference

References: 1 entry

Howard et al. 2000. Biochem J. 348 Pt 1:21-7. PMID: 10794709.


Add a reference


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