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|Antigen/Gene or Protein Targets||MSP-1 (MAD20 type)|
|Relevance||Malaria continues to be a significant health problem in India. Several of the intended Plasmodium falciparum vaccine candidate antigens are highly polymorphic. The genetic diversity of P. falciparum merozoite surface protein-1 (MSP-1) has been extensively studied from various parts of the world. The block 2 region includes three allele families: K1, MAD20, and RO33. Characterization of antigenic diversity in vaccine candidate antigens are valuable for future vaccine trials as well as understanding the population dynamics of P. falciparum parasites.|
|Immunogen||Schizonts of the PB1 isolate|
Recognises an epitope in the MAD20 allelic type of MSP-1 of P. falciparum. Target is a conformational epitope within Blocks 6 to 16.
UK Biosafety level: 1
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