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Anti-MSP1 Block 4b [12.1]

Info

Applications N/A
Antigen/Gene or Protein Targets MSP-1 Block 4 (MAD20)
Reactivity Plasmodium
Relevance In considering methods for immunological control of Plasmodium falciparum malaria it is essential to know more about antigenic diversity within and between natural populations of the parasite from major endemic areas. A successful malaria vaccine would stimulate an individual's immune system to respond to the malaria parasite and prevent serious clinical disease. Many different groups are currently developing potential vaccines. Several candidates are based on a protein called MSP1 (merozoite surface protein 1) which is found on the surface of the blood stage form of the malaria parasite.
Host Mouse
Immunogen Schizont extracts
Subclass IgG1
Myeloma Used P3/NS1/1-Ag4.1
Notes Recognises MSP-1 Block 4, C-terminal half, with the epitope sequence 334-PLPENKKKEVEG-345. This sequence is found in the MAD20 isolate. See Miller et al., 1993 Mol. Biochem. Parasitol. 59:1-14 for details of MSP-1 sequence variation
UK Biosafety level: 1
Research Area Parasitology

References: 1 entry

Conway et al. 1991. Exp Parasitol. 73(4):469-80. PMID: 1720396.


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References: 1 entry

Conway et al. 1991. Exp Parasitol. 73(4):469-80. PMID: 1720396.


Add a reference

References: 1 entry

Conway et al. 1991. Exp Parasitol. 73(4):469-80. PMID: 1720396.


Add a reference


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