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Anti-CD49e [SNAKA51]

Info

Catalogue Number 152487
Applications IF Fn WB
Antigen/Gene or Protein Targets Integrin alpha5 (CD49e)
Synonyms Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A
Reactivity Human
Relevance CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.
Host Mouse
Immunogen Whole cells corresponding to human Integrin alpha5.
Positive Control HeLa cells
Subclass IgG2a kappa
Myeloma Used P3X63Ag8.653
Notes Activity Assay: A representative lot of this antibody converts alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding.
Immunocytochemistry Analysis: A representative lot of this antibody detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF)
Research Area Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology

References

There are 4 reference entries for this reagent.

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References: 4 entries

Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Europe PMC ID: 19175293

Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.

IF

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.

Europe PMC ID: 15615773


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References: 4 entries

Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.

Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.

Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.

IF

A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.


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Inventor Information

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