Anti-CD49e [SNAKA51]
Invented at University of Manchester
- Datasheet
- References (4)
- Inventor Info
Info
![Immunofluorescence on endothelial cells transfected with mNrp1-mRFP and Rab5-GFP and then incubated with anti-CD49e [SNAKA51]. mNrp1-mRFP and active a5b1 colocalize into Rab5-GFP-positive early endosomes as shown in merging (arrowheads). Lower
panels are magnifications of the boxed areas shown in the upper panels. Taken from Valdembri et al. 2009. PLoS Biol. 7(1):e25](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,q_auto/bd8af2d6-78ba-4733-a68f-7e14cbefc274.png)
![Immunofluorescence on endothelial cells transfected with mNrp1-mRFP and Rab5-GFP and then incubated with anti-CD49e [SNAKA51]. mNrp1-mRFP and active a5b1 colocalize into Rab5-GFP-positive early endosomes as shown in merging (arrowheads). Lower
panels are magnifications of the boxed areas shown in the upper panels. Taken from Valdembri et al. 2009. PLoS Biol. 7(1):e25](https://res.cloudinary.com/ximbio/image/upload/c_limit,fl_lossy,h_282,q_auto,w_368/bd8af2d6-78ba-4733-a68f-7e14cbefc274.png)
![Image thumbnail for Anti-CD49e [SNAKA51]](https://res.cloudinary.com/ximbio/image/upload/c_fit,fl_lossy,h_45,q_auto/bd8af2d6-78ba-4733-a68f-7e14cbefc274.png)
| Catalogue Number | 152487 |
| Applications | IF Fn WB |
| Antigen/Gene or Protein Targets | Integrin alpha5 (CD49e) |
| Synonyms | Integrin Subunit Alpha 5; Fibronectin Receptor Subunit Alpha; CD49 Antigen-Like Family Member E; Integrin Alpha-F; VLA-5; FNRA; Very Late Activation Protein 5; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Fibronectin Receptor; Alpha Subunit; Fibronectin Receptor; Alpha Polypeptide; Integrin Alpha; CD49e Antigen; CD49e; VLA5A |
| Reactivity | Human |
| Relevance | CD49e is the integrin alpha 5 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 5 undergoes post translational cleavage in the extracellular domain to yield disulfide linked light and heavy chains that join with beta 1 to form a fibronectin receptor that is known variously: in lymphocytes as very late (activation) antigen 5 (VLA5); in platelets as glycoprotein IcIIa; and in fibroblasts as extracellular matrix receptor 6 (ECMVI). In addition to adhesion, integrins are known to participate in cell surface mediated signalling. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. |
| Host | Mouse |
| Immunogen | Whole cells corresponding to human Integrin alpha5. |
| Positive Control | HeLa cells |
| Subclass | IgG2a kappa |
| Myeloma Used | P3X63Ag8.653 |
| Notes |
Activity Assay: A representative lot of this antibody converts alpha5 beta1 integrin into a ligand competant form and promotes fibronectin binding. Immunocytochemistry Analysis: A representative lot of this antibody detected Integin alpha 5 in Primary human foreskin fibroblasts (hFF) |
| Research Area | Adhesion, Apoptosis and Programmed Cell Death, Cell Signaling & Signal Transduction, Immunology |
References: 4 entries
Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
Europe PMC ID: 19175293
Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
IF
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Europe PMC ID: 15615773
Add a reference
References: 4 entries
Valdembri et al. 2009. PLoS Biol. 7(1):e25. PMID: 19175293.
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells.
Clark et al. 2005. J Cell Sci. 118(Pt 2):291-300. PMID: 15615773.
IF
A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation.
Add a reference
