Cancer Research Technology
Log in Register
Menu

Anti-CD29 [12G10]

Info

Catalogue Number 152482
Applications ELISA FACS IHC IF IP WB
Antigen/Gene or Protein Targets CD29 (Integrin b1 chain)
Synonyms Integrin Subunit Beta 1; Glycoprotein Iia; MSK12; GPIIA; FNRB; MDF2; Very Late Activation Protein; Beta Polypeptide; Fibronectin Receptor Subunit Beta; Integrin VLA-4 Beta Subunit; CD29 Antigen; VLA-BETA; CD29; VLAB
Reactivity Human
Relevance CD29 is a member of the family of integrins, membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells.
Host Mouse
Immunogen Purified human β1 integrin preparation from HT1080 fibrosarcoma cell extract.
Subclass IgG1
Myeloma Used P3X63Ag8.653
Notes 12G10 has been shown to recognize a ligand-induced binding site of human β1 integrin. The binding is increased in the presence of a
fibronectin ligand. This antibody also enhances alpha 5 – beta 1 fibronectin interactions.
12G10 does not cross-react with mouse or rat samples.
Research Area Adhesion, Cancer, Cell Signaling & Signal Transduction, Epigenetics & Nuclear Signalling, Gene Expression, Immunology

References

There are 18 reference entries for this reagent.

View All References

References: 18 entries

Chen et al. 2009. PLoS One. 4(8):e6565. PMID: 19668337.

IF

MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation.

Europe PMC ID: 19668337

Yamamoto et al. 2009. Endocrinology. 150(2):990-9. PMID: 18845630.

N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin.

Europe PMC ID: 18845630

Yamamoto et al. 2007. Br J Cancer. 97(11):1538-44. PMID: 17971775.

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis.

Europe PMC ID: 17971775

Cavallo-Medved et al. 2005. J Cell Sci. 118(Pt 7):1493-503. PMID: 15769846.

Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.

Europe PMC ID: 15769846

Avizienyte et al. 2002. Nat Cell Biol. 4(8):632-8. PMID: 12134161.

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Europe PMC ID: 12134161

Iba et al. 2000. J Cell Biol. 149(5):1143-56. PMID: 10831617.

The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

Europe PMC ID: 10831617

Mould et al. 1998. Biochem J. 331 ( Pt 3):821-8. PMID: 9560310.

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

Europe PMC ID: 9560310

Mould et al. 1995. Biochem Soc Trans. 23(3):395S. PMID: 8566283.

Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations.

Europe PMC ID: 8566283

Mould et al. 1995. FEBS Lett. 363(1-2):118-22. PMID: 7537221.

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit.

Europe PMC ID: 7537221


Add a reference

References: 18 entries

Chen et al. 2009. PLoS One. 4(8):e6565. PMID: 19668337.

IF

MMP7 shedding of syndecan-1 facilitates re-epithelialization by affecting alpha(2)beta(1) integrin activation.

Yamamoto et al. 2009. Endocrinology. 150(2):990-9. PMID: 18845630.

N-acetylglucosaminyltransferase V regulates extravillous trophoblast invasion through glycosylation of alpha5beta1 integrin.

Yamamoto et al. 2007. Br J Cancer. 97(11):1538-44. PMID: 17971775.

Expression of N-acetylglucosaminyltransferase V in endometrial cancer correlates with poor prognosis.

Cavallo-Medved et al. 2005. J Cell Sci. 118(Pt 7):1493-503. PMID: 15769846.

Caveolin-1 mediates the expression and localization of cathepsin B, pro-urokinase plasminogen activator and their cell-surface receptors in human colorectal carcinoma cells.

Avizienyte et al. 2002. Nat Cell Biol. 4(8):632-8. PMID: 12134161.

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling.

Iba et al. 2000. J Cell Biol. 149(5):1143-56. PMID: 10831617.

The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading.

Mould et al. 1998. Biochem J. 331 ( Pt 3):821-8. PMID: 9560310.

Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1.

Mould et al. 1995. Biochem Soc Trans. 23(3):395S. PMID: 8566283.

Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations.

Mould et al. 1995. FEBS Lett. 363(1-2):118-22. PMID: 7537221.

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit.


Add a reference

Inventor Information

No inventors are currently linked to this reagent.

Add an inventor