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Monoclonal Antibodies

Anti-HSV gD [AP12]

Invented by Anthony Minson
Invented at University of Cambridge
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Applications IHC IF IP
Antigen/Gene or Protein Targets Herpes Simplex Virus Glycoprotein D (HSV gD)
Reactivity Virus
Relevance The envelope of herpes simplex virus (HSV) is complex, as it contains at least 10 virus-encoded glycoproteins. However, only a subset of these mediate virus entry in cell culture. The initial interaction of HSV with cell surface heparan sulfate proteoglycans is mediated by glycoprotein C (gC) and/or gB. This is presumably followed by interaction of one or more of the viral glycoproteins with cellular receptors. Then gD, gB, and the complex of gH and gL act individually or in combination to trigger pH-independent fusion of the viral envelope with the host cell plasma membrane
Host Mouse
Subclass IgG1
Notes Works well for immunofluorescence (IF) on fixed specimens and for immunoprecipitiation (IP) on triton solubilised samples. Does not work in Western blots. The antibody epitope is well characterised by binding competition assays and by sequencing of antibody escape mutants.
Research Area Virology

References

There are 1 reference entries for this reagent.

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References: 1 entry

Minson et al. 1986. J Gen Virol. 67 ( Pt 6):1001-13. PMID: 2423636.

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References: 1 entry

Minson et al. 1986. J Gen Virol. 67 ( Pt 6):1001-13. PMID: 2423636.

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Inventor Information