Anti-HSV gD [LP2]

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References (2)

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Applications	FACS IHC IF IP
Antigen/Gene or Protein Targets	Herpes Simplex Virus Glycoprotein D (HSV gD)
Reactivity	Virus
Relevance	The envelope of herpes simplex virus (HSV) is complex, as it contains at least 10 virus-encoded glycoproteins. However, only a subset of these mediate virus entry in cell culture. The initial interaction of HSV with cell surface heparan sulfate proteoglycans is mediated by glycoprotein C (gC) and/or gB. This is presumably followed by interaction of one or more of the viral glycoproteins with cellular receptors. Then gD, gB, and the complex of gH and gL act individually or in combination to trigger pH-independent fusion of the viral envelope with the host cell plasma membrane.
Host	Mouse
Immunogen	Herpes Simplex Virus Type-1 and Type-2 envelope protein Glycoprotein D
Subclass	IgG2a
Notes	Clone LP2 strongly neutralises virus in the absence of Complement. Works well for immunofluorescence (IF) on fixed specimens, for immunoprecipitiation (IP) on triton solubilised samples and flow cytometry. Does not work in Western blots. The antibody epitope is well characterised by binding competition assays and by sequencing of antibody escape mutants.
Research Area	Virology

There are 2 reference entries for this reagent.

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Buckmaster et al. 1984. J Med Virol. 13(2):193-202. PMID: 6319591.

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Minson et al. 1986. J Gen Virol. 67 ( Pt 6):1001-13. PMID: 2423636.

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Buckmaster et al. 1984. J Med Virol. 13(2):193-202. PMID: 6319591.

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Minson et al. 1986. J Gen Virol. 67 ( Pt 6):1001-13. PMID: 2423636.

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Anthony Minson

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	University of Cambridge
	114 reagents listed on Ximbio