Anti-Tie-2R [4G8HE]
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Info
| Applications | ELISA FACS IP WB |
| Antigen/Gene or Protein Targets | Tie-2R |
| Synonyms | TEK Receptor Tyrosine Kinase; Tyrosine Kinase With Ig And EGF Homology Domains-2; Tunica Interna Endothelial Cell Kinase; Tyrosine-Protein Kinase Receptor TIE-2; Endothelial Tyrosine Kinase; VMCM1; TIE2; Venous Malformations; Multiple Cutaneous And Mucosal; CD202b Antigen; P140 TEK; CD202B; TIE-2; HTIE2 |
| Reactivity | Mouse |
| Relevance | Tie-2 is a 145 kD type I transmembrane protein, also known as CD202b or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of Tie-2 to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of Tie-2, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 binds to Ang-4 as well. |
| Host | Rat |
| Subclass | IgG1 |
| Research Area | Cancer, Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Developmental Biology, Stem Cell Biology |
References: 1 entry
References: 1 entry
References: 1 entry
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