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Applications
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ELISA
FACS
IP
WB
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Antigen/Gene or Protein Targets
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Tie-2R
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Synonyms
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TEK Receptor Tyrosine Kinase; Tyrosine Kinase With Ig And EGF Homology Domains-2; Tunica Interna Endothelial Cell Kinase; Tyrosine-Protein Kinase Receptor TIE-2; Endothelial Tyrosine Kinase; VMCM1; TIE2; Venous Malformations; Multiple Cutaneous And Mucosal; CD202b Antigen; P140 TEK; CD202B; TIE-2; HTIE2
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Reactivity
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Mouse
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Relevance
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Tie-2 is a 145 kD type I transmembrane protein, also known as CD202b or TEK. It is a member of the receptor tyrosine kinase (RTK) family of proteins and is expressed by endothelial cells and their progenitors, quiescent hematopoietic stem cells (HSCs), and a subpopulation of monocytes. Angiopoietin-1 (Ang-1) is an activator of Tie-2 to promote, maintain, and stabilize mature vessels and to maintain HSCs in quiescent state. Ang-2 is another ligand of Tie-2, which is involved in postnatal angiogenesis and in antagonizing the effects of Ang-1. Tie-2 binds to Ang-4 as well.
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Host
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Rat
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Subclass
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IgG1
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Research Area
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Cancer, Cardiovascular, Cell Type or Organelle Marker, Cell Signaling & Signal Transduction, Developmental Biology, Stem Cell Biology
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