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Anti-TAF10 [6TA-2F4]

Info

Applications ELISA IF IP WB
Antigen/Gene or Protein Targets TAF10 
Reactivity Human
Relevance Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the small subunits of TFIID that is associated with a subset of TFIID complexes. Studies with human and mammalian cells have shown that this subunit is required for transcriptional activation by the estrogen receptor, for progression through the cell cycle, and may also be required for certain cellular differentiation programs.
Host Mouse
Immunogen Full length human TAF10 as a fusion protein
Subclass IgG1 kappa
Notes Recognises the GGPGAGAAAGGTG epitope from aa. 50-62

Available in 100ul unit as ascites

Recommended dilution of 1/500 - 1/5000
Research Area Epigenetics & Nuclear Signalling

References: 3 entries

Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.

Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.

Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.


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References: 3 entries

Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.

Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.

Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.


Add a reference

References: 3 entries

Metzger et al. 1999. EMBO J. 18(17):4823-34. PMID: 10469660.

Wieczorek et al. 1998. Nature. 393(6681):187-91. PMID: 9603525.

Jacq et al. 1994. Cell. 79(1):107-17. PMID: 7923369.


Add a reference


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