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Anti-HP-1a [2HP-2G9]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  Heterochromatin Protein 1a (HP-1 a) 
Reactivity Human and Mouse
Relevance The anti‐Heterochromatin protein‐1 a, clone 2HP‐2G9, is specific for Hp1a protein from mouse and human, epitope between aa 67 and 119. The family of Heterochromatin Protein 1 (HP1) consists of highly conserved proteins, which have important functions in the cell nucleus. These functions include gene repression by heterochromatin formation, transcriptional activation, regulation of binding of cohesion complexes to centromeres, sequesteration of genes to nuclear periphery, transcriptional arrest, maintenance of heterochromatin integrity, gene repression at the single nucleosome level and gene repression by heterochromatization of euchromatin. In mammals there are three paralogs: HP1α, HP1β and HP1γ.
Host Mouse
Immunogen Recombinant mouse HP1 alpha (AA 67-119)
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.
Research Area Epigenetics & Nuclear Signalling

References: 2 entries

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.

Remboutsika et al. 1999. J Cell Sci. 112 ( Pt 11):1671-83. PMID: 10318760.


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References: 2 entries

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.

Remboutsika et al. 1999. J Cell Sci. 112 ( Pt 11):1671-83. PMID: 10318760.


Add a reference

References: 2 entries

Nielsen et al. 1999. EMBO J. 18(22):6385-95. PMID: 10562550.

Remboutsika et al. 1999. J Cell Sci. 112 ( Pt 11):1671-83. PMID: 10318760.


Add a reference


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