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Anti-ETS1 [3ET-1C10]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  ETS1 (C-terminal region) 
Reactivity Human
Relevance The Anti‐Ets1 (C‐terminal region) clone 3ET‐1C10 has been validated for ELISA, Western blot and Immunofluorescence. ETS1 belongs to the ETS family of transcription factors. Ets1 is expressed at high levels mainly in immune tissues such as thymus, spleen, and lymph node (B cells, T cells, NK cells, and NK T cells and non-lymphoid immune cells). An enforced expression of Ets1 blocks differentiation of B- and T-cells, whereas knocking Ets1 down causes multiple defects in the immune system. Meta-analyses of multiple genome-wide association studies has suggested an association of SNPs in the ETS1 locus with psoriasis in European populations. This is not surprising because Ets1 is a negative regulator of Th17 cells. Ets1 overexpression in stratified squamous epithelial cells causes pro-oncogenic changes, such as suspension of terminal differentiation, high secretion of matrix metalloproteases (Mmps), epidermal growth factor ligands, and inflammatory mediators.
Host Mouse
Immunogen CEELHAMLDVKPDADE (C-terminal region)
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

Recommended dilution : 1/500 – 1/ 5000
Research Area Cancer, Cardiovascular, Epigenetics & Nuclear Signalling, Immunology

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