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Anti-E6 [2E-3F8]

Info

Applications ELISA IF WB
Antigen/Gene or Protein Targets  E6 Papillomavirus Type16 
Reactivity Virus
Relevance The E6 of human papillomavirus type 16 (HPV16) is a 158 aa protein expressed in transformed human cells after infection. E6 protein mediates the degradation of the cellular p53 tumour suppressor protein. It activates transcription of the telomerase gene and acts as a DNA binding protein with high affinity for four-way DNA junctions. In addition to p53, E6 interacts with a variety of cellular proteins, of which a significant number act at the transcriptional level. E6 is present in a large number of cervical carcinomas.
Host Mouse
Immunogen Human papillomavirus type 16 (HPV16) E6 fragment from K101 to R151 as a fusion protein.
Subclass IgG2a kappa
Notes Available in 100ul unit as ascites.
Research Area Cancer, Virology

References: 1 entry

Lagrange et al. 2005. J Gen Virol. 86(Pt 4):1001-7. PMID: 15784893.


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References: 1 entry

Lagrange et al. 2005. J Gen Virol. 86(Pt 4):1001-7. PMID: 15784893.


Add a reference

References: 1 entry

Lagrange et al. 2005. J Gen Virol. 86(Pt 4):1001-7. PMID: 15784893.


Add a reference


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