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Anti-ALDP [2AL-1D6]

Info

Applications IHC IF WB
Antigen/Gene or Protein Targets  ALDP (Adenoleucodistrophy protein)
Reactivity Human
Relevance The Anti-ALDP antibody, clone 2AL-1D6, can be used in western blot, immunofluorescence or immunohistochemical studies to analyse the ALDP protein in cells and tissues for normal individuals, or from patients with adrenoleukodystrophy (ALD) or Zellweger syndrome and related peroxisomal diseases, and provides an excellent marker for peroxisomes (Mosser et al. 1994). About 70% of ALD male patients have no detectable ALDP in fibroblasts or leukocytes. A similar proportion of carrier females may show mosaïcism for the presence or absence of ALDP.
Host Mouse
Immunogen Recombinant protein protein (279-482)
Subclass IgG1 kappa
Notes Available in 100ul unit as ascites.

No cross-reaction on mouse ALDP, mouse ALDRP, PMP70
Cross-reaction on an unidentified 80 kd MW protein present in lymphoblastoid cells, but not in several other cells or tissues tested
Research Area Cellular Transport, Neurobiology

References: 3 entries

Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.

Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.

Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.


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References: 3 entries

Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.

Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.

Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.


Add a reference

References: 3 entries

Aubourg et al. 1996. Ann N Y Acad Sci. 804:461-76. PMID: 8993565.

Lombard-Platet et al. 1996. Proc Natl Acad Sci U S A. 93(3):1265-9. PMID: 8577752.

Mosser et al. 1994. Hum Mol Genet. 3(2):265-71. PMID: 8004093.


Add a reference


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