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Anti-XPC Polyclonal [RW028]

Info

Catalogue Number 152161
Applications IF WB
Antigen/Gene or Protein Targets Xeroderma Pigmentosum Group C (XPC)
Reactivity Human
Relevance Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity.
Host Rabbit
Immunogen 96-299 of human XPC protein
Notes This antibody is not available for licence, please refer to supplier information to find a source of the antibody.
Positive Control HeLa cell lysate
Research Area DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 13 entries

HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.

Europe PMC ID: 23209410

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

IF

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

WB

Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504.

WB

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

Europe PMC ID: 19446504

Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551.

WB

Atypical protein kinase C stimulates nucleotide excision repair activity.

Europe PMC ID: 15358551

Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.

WB

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.

Europe PMC ID: 11259578

Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465.

WB

Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

Europe PMC ID: 10873465

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

WB

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

Europe PMC ID: 10074455


Add a reference

References: 13 entries

HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.

Europe PMC ID: 23209410

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

IF

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

WB

Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504.

WB

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

Europe PMC ID: 19446504

Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551.

WB

Atypical protein kinase C stimulates nucleotide excision repair activity.

Europe PMC ID: 15358551

Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.

WB

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.

Europe PMC ID: 11259578

Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465.

WB

Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

Europe PMC ID: 10873465

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

WB

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.

Europe PMC ID: 10074455


Add a reference

References: 13 entries

HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

IF

O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.

WB

Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504.

WB

Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.

Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551.

WB

Atypical protein kinase C stimulates nucleotide excision repair activity.

Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.

WB

Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.

Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465.

WB

Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.

Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.

WB

Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.


Add a reference


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