Anti-XPC Polyclonal [RW028]
Invented at Cancer Research UK London Research Institute: Lincoln's Inn Fields
- Datasheet
- References (13)
- Inventor Info
Info
| Catalogue Number | 152161 |
| Applications | IF WB |
| Antigen/Gene or Protein Targets | Xeroderma Pigmentosum Group C (XPC) |
| Reactivity | Human |
| Relevance | Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. |
| Host | Rabbit |
| Immunogen | 96-299 of human XPC protein |
| Notes | This antibody is not available for licence, please refer to supplier information to find a source of the antibody. |
| Positive Control | HeLa cell lysate |
| Research Area | DNA Damage and Repair, Epigenetics & Nuclear Signalling |
References: 13 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
Europe PMC ID: 23209410
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
WB
Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504.
WB
Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.
Europe PMC ID: 19446504
Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551.
WB
Atypical protein kinase C stimulates nucleotide excision repair activity.
Europe PMC ID: 15358551
Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.
WB
Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
Europe PMC ID: 11259578
Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465.
WB
Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.
Europe PMC ID: 10873465
Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
WB
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Europe PMC ID: 10074455
Add a reference
References: 13 entries
HCMV-infected cells maintain efficient nucleotide excision repair of the viral genome while abrogating repair of the host genome.
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
IF
O'Dowd et al. 2012. PLoS Pathog. 8(11):e1003038. PMID: 23209410.
WB
Lange et al. 2009. DNA Repair (Amst). 8(7):865-72. PMID: 19446504.
WB
Human HMGB1 directly facilitates interactions between nucleotide excision repair proteins on triplex-directed psoralen interstrand crosslinks.
Louat et al. 2004. FEBS Lett. 574(1-3):121-5. PMID: 15358551.
WB
Atypical protein kinase C stimulates nucleotide excision repair activity.
Araújo et al. 2001. Mol Cell Biol. 21(7):2281-91. PMID: 11259578.
WB
Strong functional interactions of TFIIH with XPC and XPG in human DNA nucleotide excision repair, without a preassembled repairosome.
Batty et al. 2000. J Mol Biol. 300(2):275-90. PMID: 10873465.
WB
Stable binding of human XPC complex to irradiated DNA confers strong discrimination for damaged sites.
Köberle et al. 1999. Curr Biol. 9(5):273-6. PMID: 10074455.
WB
Defective repair of cisplatin-induced DNA damage caused by reduced XPA protein in testicular germ cell tumours.
Add a reference
