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Anti-HHV-8 LNA-1 [LN53]

Info

Catalogue Number 152152
Applications ELISA FACS IHC IP WB
Antigen/Gene or Protein Targets Latent nuclear antigen 1 (LNA-1; ORF73) of HHV-8
Synonyms ORF-73 of human herpesvirus 8 or HHV-8 positive cells
Reactivity Virus
Relevance Human herpesvirus-8 has been found to be associated with three different diseases observed in AIDS patients; Kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV-8 in Kaposi's sarcoma. HHV-8 encodes a latent nuclear antigen (LNA-1) which is the product of the viral gene orf 73. LNA-1 is recognized by most infected patient sera and is the basis of current immunofluorescence assays used in epidemiological studies of HHV-8 infection.
Host Rat
Immunogen Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV-8
Subclass IgG2c
Notes LN53 recognizes the epitope EQEQE. The LN53 epitope is contained within the repetitive region of LNA-1, resulting in 23 copies of the LN53 epitope in full-length LNA-1.

LN53 reacts to Human herpesvirus 8.
Research Area Virology

References: 10 entries

Brouchet et al. 2005. Br J Cancer. 92(4):743-6. PMID: 15700034.

IHC

Detection of oncogenic virus genomes and gene products in lung carcinoma.

Europe PMC ID: 15700034

Caussinus et al. 2001. J Clin Pathol. 54(10):790-1. PMID: 11577129.

IHC

Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event?

Europe PMC ID: 11577129

Gomez-Brouchet et al. 2001. J Clin Pathol. 54(8):617-8. PMID: 11477117.

IHC

Immunohistochemical assessment of human herpesvirus 8 infection in primary central nervous system large B cell lymphomas.

Europe PMC ID: 11477117

Kellam et al. 1999. J Virol. 73(6):5149-55. PMID: 10233979.

ELISA WB FACS IHC IP

Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8.

Europe PMC ID: 10233979

Dupin et al. 1999. Proc Natl Acad Sci U S A. 96(8):4546-51. PMID: 10200299.

IHC

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.

Europe PMC ID: 10200299


Add a reference

References: 10 entries

Brouchet et al. 2005. Br J Cancer. 92(4):743-6. PMID: 15700034.

IHC

Detection of oncogenic virus genomes and gene products in lung carcinoma.

Europe PMC ID: 15700034

Caussinus et al. 2001. J Clin Pathol. 54(10):790-1. PMID: 11577129.

IHC

Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event?

Europe PMC ID: 11577129

Gomez-Brouchet et al. 2001. J Clin Pathol. 54(8):617-8. PMID: 11477117.

IHC

Immunohistochemical assessment of human herpesvirus 8 infection in primary central nervous system large B cell lymphomas.

Europe PMC ID: 11477117

Kellam et al. 1999. J Virol. 73(6):5149-55. PMID: 10233979.

ELISA WB FACS IHC IP

Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8.

Europe PMC ID: 10233979

Dupin et al. 1999. Proc Natl Acad Sci U S A. 96(8):4546-51. PMID: 10200299.

IHC

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.

Europe PMC ID: 10200299


Add a reference

References: 10 entries

Brouchet et al. 2005. Br J Cancer. 92(4):743-6. PMID: 15700034.

IHC

Detection of oncogenic virus genomes and gene products in lung carcinoma.

Caussinus et al. 2001. J Clin Pathol. 54(10):790-1. PMID: 11577129.

IHC

Simultaneous occurrence of Epstein-Barr virus associated Hodgkin's disease and HHV-8 related multicentric Castleman's disease: a fortuitous event?

Gomez-Brouchet et al. 2001. J Clin Pathol. 54(8):617-8. PMID: 11477117.

IHC

Immunohistochemical assessment of human herpesvirus 8 infection in primary central nervous system large B cell lymphomas.

Kellam et al. 1999. J Virol. 73(6):5149-55. PMID: 10233979.

ELISA WB FACS IHC IP

Characterization of monoclonal antibodies raised against the latent nuclear antigen of human herpesvirus 8.

Dupin et al. 1999. Proc Natl Acad Sci U S A. 96(8):4546-51. PMID: 10200299.

IHC

Distribution of human herpesvirus-8 latently infected cells in Kaposi's sarcoma, multicentric Castleman's disease, and primary effusion lymphoma.


Add a reference


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