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Monoclonal Antibodies

Anti-Cytochrome P450 51A1 [N6-P2H5*G8]

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited
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Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
Image thumbnail for Anti-Cytochrome P450 51A1 [N6-P2H5*G8]
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Photomicrograph of normal tissue IHC using N6-P2H5*G8
Photomicrograph of primary tumour IHC using N6-P2H5*G8
Photomicrograph of metastatic tissue IHC using N6-P2H5*G8
Photomicrograph of liver tissue IHC using N6-P2H5*G8
Photomicrograph of colon tissue IHC using N6-P2H5*G8
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Catalogue Number 152123
Applications ELISA IHC WB
Antigen/Gene or Protein Targets CYP51A1- Cytochrome P450, family 51, subfamily A, polypeptide 1.
Reactivity Human
Relevance Cytochrome P450, family 51, subfamily A, polypeptide 1 (CYP51A1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP51A1 is an endoplasmic reticulum protein that participates in the synthesis of cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide NPVIRYKRRS (C-terminal sequence).
Positive Control WB: pooled human liver microsomes
Subclass IgG1 kappa
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing L-Glutamine and 20% Fetal Bovine serum (DH20).
Notes This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References

There are 2 reference entries for this reagent.

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References: 2 entries

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.

Europe PMC ID: 27341022

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Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB

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References: 2 entries

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.

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Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB

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Inventor Information