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Anti-Cytochrome P450 2R1 [M26-P6H1]

Invented by Ayham Alnabulsi at Vertebrate Antibodies Limited

Info

Catalogue Number 152121
Applications ELISA IHC WB
Antigen/Gene or Protein Targets CYP2R1, Cytochrome P450, family 2, subfamily R, polypeptide 1.
Reactivity Human and Mouse
Relevance Cytochrome P450 2R1 (CYP2R1) encodes a member of the cytochrome P450 superfamily of enzymes that are a group of heme-thiolate monooxygenases. Cytochromes P450 catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. CYP2R1 expressed in the liver is a microsomal vitamin D hydroxylase that converts vitamin D into 25-hydroxyvitamin D (calcidiol), the major circulatory form of the vitamin.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide QPYLICAERR (C-terminal sequence).
Positive Control IHC: formalin-fixed, paraffin-embedded human kidney sections. WB: pooled liver microsomes.
Myeloma Used P3X63Ag8.653
Recommended Growing Conditions Dulbecco’s media containing 20% Fetal Bovine serum (DH20) prepared as follows (for final volume of 300ml: 237ml DMEM plus 60 ml Fetal Bovine Serum plus 3ml L-Glutamine).
Notes This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism

References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


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References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


Add a reference

References: 1 entry

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


Add a reference


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