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Anti-Cytochrome P450 7B1 [M17-P3F2]

Invented by Ayham Alnabulsi from Vertebrate Antibodies Limited
Invented at Vertebrate Antibodies Limited

Info

Catalogue Number 152117
Applications ELISA IHC WB
Antigen/Gene or Protein Targets Cytochrome P450, family 7, subfamily B, polypeptide 1 (CYP7B1)
Reactivity Human
Relevance Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
Host Mouse
Immunogen Ovalbumin-conjugated synthetic peptide IQYPDSDVL (C-terminal sequence)
Positive Control IHC: formalin-fixed, paraffin-embedded human liver sections WB: pooled human liver microsomes
Subclass IgG1 lambda
Myeloma Used P3X63Ag8.653
Strain Balb/c
Notes This antibody was applied in a poster presented at the 2015 NCRI conference: http://abstracts.ncri.org.uk/?s=oxysterol&year_published=2015
Research Area Cancer, Cardiovascular, Cell Signaling & Signal Transduction, Metabolism, Neurobiology

References

There are 2 reference entries for this reagent.

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References: 2 entries

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.

Europe PMC ID: 27341022

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


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References: 2 entries

Characterisation of the oxysterol metabolising enzyme pathway in mismatch repair proficient and deficient colorectal cancer.

Swan et al. 2016. Oncotarget. :. PMID: 27341022.

IHC WB


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