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Anti-Ubiquitinated Histone H2B (Lys123) [1B3F12/A9]
RECENTLY UPDATED

Invented by Alfred Nijkerk at UbiQ Bio

Info

Catalogue Number 152107
Applications ChIP ELISA WB
Antigen/Gene or Protein Targets Yeast monoubiquityl-histone H2B
Reactivity Human, Schizosaccharomyces pombe and Saccharomyces cerevisiae
Relevance C-terminus monoubiquitination of histone H2B acts as a signal for downstream processes such as gene regulation, genome packaging, histone modification crosstalk, and DNA repair. How the ubiquitination levels are controlled and how the Ub signal is translated to downstream effects is poorly understood. An antibody that detects K123 monoubiquitinated yeast H2B, homologue to human H2B K120, will enable research to discover the fundamental principles of the regulation and function of monoubiquitination of H2B. The antibody is developed using an ubiquitin-polypeptide antigen based on the amino-acids 115-130 of the yeast H2B protein, linked by a proteolytically stable bond.
Host Mouse
Immunogen Ub-polypeptide antigen based on amino acids 115 - 130 of yeast H2B
Subclass IgG1
Positive Control Yeast histone preparation
Molecular Weight (kDa) 23
Notes Clone formerly called "H2BK123"
Research Area
RECENTLY UPDATED
DNA Damage and Repair, Epigenetics & Nuclear Signalling

References: 1 entry

Vlaming et al. 2016. Elife. 5:. PMID: 27922451.

ChIP WB


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References: 1 entry

Vlaming et al. 2016. Elife. 5:. PMID: 27922451.

ChIP WB


Add a reference

References: 1 entry

Vlaming et al. 2016. Elife. 5:. PMID: 27922451.

ChIP WB


Add a reference


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