pJEK21 Gamma-Synuclein Vector
Invented by Dr Fiona Benson from Lancaster University
Invented at Lancaster University
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| Catalogue Number | 152050 |
| Relevance | Gamma synuclein is structurally related to alpha-synuclein. Due to these structural similarities, gamma-synuclein can also aggregate in vitro and in vivo. This aggregation is believed to be a crucial trigger of neurodegeneration in alpha-synucleinopathies. Motor neurones express high levels of gamma-synuclein, with the protein highly abundant in their axons, where it might affect organisation of axonal cytoskeleton. |
| Research Area | Neurobiology |
| Notes | pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (γ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct γ-synuclein is expressed as a fusion protein with an N-terminal six His tag. |
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