Cat. #152050
pJEK21 Gamma-Synuclein Vector
Cat. #: 152050
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Contributor
Inventor: Dr Fiona Benson
Institute: Lancaster University
Tool Details
*FOR RESEARCH USE ONLY
- Tool name: pJEK21 Gamma-Synuclein Vector
- Description: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (ÄÂÄšÂ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct ÄÂÄšÂ-synuclein is expressed as a fusion protein with an N-terminal six His tag.
- Additional notes: Gamma synuclein is structurally related to alpha-synuclein. Due to these structural similarities, gamma-synuclein can also aggregate in vitro and in vivo. This aggregation is believed to be a crucial trigger of neurodegeneration in alpha-synucleinopathies. Motor neurones express high levels of gamma-synuclein, with the protein highly abundant in their axons, where it might affect organisation of axonal cytoskeleton.
Application Details
- Application notes: pJEK21 is a derivative of pET15b with the open reading frame encoding the human gamma-synuclein (γ-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct γ-synuclein is expressed as a fusion protein with an N-terminal six His tag.
