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Beta-synuclein is an abundant pre-synaptic phosphoprotein that is found in the brain and is homolgous to alpha-synuclein. Beta-synuclein is distinct from alha-synuclein in that it lacks the majority of the hydrophobic non-amyloid-beta component of the Alzeheimer's disease amyloid region. Due to this beta-synuclein is less likely to form insoluble aggregates when compared to alpha-synuclein. It is thought that beta-synuclein may have a protective role against alpha-synucleinopathies.
Beta-synuclein is an acidic, neuronal protein considered to be a non-amyloidogenic homolog of alpha-synuclein. It has been postulated that beta-synuclein could act as a physiological inhibitor of α-synuclein aggregation and thus protect the central nervous system from the neurotoxic effects of alpha-synuclein
|Notes||pJEK11 is a derivative of pET15b with the open reading frame encoding the human beta-synuclein (β-synuclein) cloned in via the NdeI and BamHI restriction sites. In this construct β-synuclein is expressed as a fusion protein with an N-terminal six His tag.|
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