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Anti-SMN2 [SMN-KH]

Info

Applications IHC WB
Antigen/Gene or Protein Targets SMN2
Reactivity Human
Relevance Survival motor neuron (SMN) protein is expressed from two linked paralogous genes: Survival of motor neuron 1, telomeric (SMN1) and Survival of motor neuron 2, centromeric (SMN2). SMNs are primarily localized in the cytoplasm and nuclear gems of all cells, where they are understood to mediate the assembly of spliceosomal small nuclear ribonucleoprotein particles (snRNPs). The progressive loss of functional SMNs in the anterior horn of the spinal cord is a critical cause of Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disease. There are three known types of childhood-onset SMA, in addition to a fourth type that is characterized by adult-onset SMA.
Host Mouse
Immunogen MBP-tagged recombinant protein corresponding to human SMN2
Subclass IgG1 kappa
Research Area Epigenetics & Nuclear Signalling, Neurobiology

References: 1 entry

Hua et al. 2010. Genes Dev. 24(15):1634-44. PMID: 20624852.


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References: 1 entry

Hua et al. 2010. Genes Dev. 24(15):1634-44. PMID: 20624852.


Add a reference

References: 1 entry

Hua et al. 2010. Genes Dev. 24(15):1634-44. PMID: 20624852.


Add a reference


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