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|Antigen/Gene or Protein Targets||PTP1B|
PTP1B is an intracellular protein tyrosine phosphatase. In its reduced, active state, which is the basal state of the enzyme, PTP1B regulates a number of signalling pathways. For example, PTP1B activity antagonizes insulin signalling and modulates EGF and leptin signaling. PTP1B is indicated in a number of human diseases, such as obesity and diabetes.
scFvs 45 is a conformation-sensor antibody, in the form of single chain variable fragments (scFvs), that stabilize PTP1B-oxidised (PTP1B-OX) and thereby inhibit its phosphatase function. Expression of conformation sensor scFvs as intrabodies enhanced insulin-induced tyrosyl phosphorylation of the β-subunit of the insulin receptor and its substrate IRS-1, and increased insulin induced phosphorylation of PKB/AKT.
|Immunogen||Recombinant protein corresponding to the PTP1B-OX of human PTP1B (Oxidized).|
|Research Area||Cardiovascular, Cell Signaling & Signal Transduction|
Immunogen: Recombinant protein corresponding to human PTP1B-OX
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