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Anti-PTP1B-OX, Recombinant [scFvs 45]

Info

Applications IP Fn
Antigen/Gene or Protein Targets PTP1B
Reactivity Human
Relevance PTP1B is an intracellular protein tyrosine phosphatase. In its reduced, active state, which is the basal state of the enzyme, PTP1B regulates a number of signalling pathways. For example, PTP1B activity antagonizes insulin signalling and modulates EGF and leptin signaling. PTP1B is indicated in a number of human diseases, such as obesity and diabetes.

scFvs 45 is a conformation-sensor antibody, in the form of single chain variable fragments (scFvs), that stabilize PTP1B-oxidised (PTP1B-OX) and thereby inhibit its phosphatase function. Expression of conformation sensor scFvs as intrabodies enhanced insulin-induced tyrosyl phosphorylation of the β-subunit of the insulin receptor and its substrate IRS-1, and increased insulin induced phosphorylation of PKB/AKT.
Immunogen Recombinant protein corresponding to the PTP1B-OX of human PTP1B (Oxidized).
Subclass IgG
Research Area Cardiovascular, Cell Signaling & Signal Transduction
Notes Host: Chicken

Immunogen: Recombinant protein corresponding to human PTP1B-OX

References: 2 entries

Haque et al. 2012. Nat Protoc. 7(12):2127-43. PMID: 23154784.

Haque et al. 2011. Cell. 147(1):185-98. PMID: 21962515.


Add a reference

References: 2 entries

Haque et al. 2012. Nat Protoc. 7(12):2127-43. PMID: 23154784.

Haque et al. 2011. Cell. 147(1):185-98. PMID: 21962515.


Add a reference

References: 2 entries

Haque et al. 2012. Nat Protoc. 7(12):2127-43. PMID: 23154784.

Haque et al. 2011. Cell. 147(1):185-98. PMID: 21962515.


Add a reference


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