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Fluorescent Probe FITC-Trehalose Small Molecule (Tool Compound)

Info

Antigen/Gene or Protein Targets Extracellular Ag85 enzymes of M. tuberculosis
Type Fluorescent Probe
Relevance The fluorescent Probe FITC-Trehalose is a fluorescent small-molecule probe to selectively label M. tuberculosis in culture and also in infected macrophages.
Molecular Formula C34H36N2O15S
lUPAC 1-Deoxy-α-D-gluco-hept-2-ulopyranosyl-(2→1)-2-deoxy-2-(N'-(fluorescein-5-yl)-thioureido)-α-D-glucopyranoside
Molecular Weight (g/mol) 744.72
In vivo applications These compounds are incorporated into the cell envelope of mycobacteria, via the extracellular Ag85-enzymes, providing a means of detecting live organisms. These are the first small molecules that can be used to label and image tuberculosis in a selective manner in vivo.
Research Area Bacteriology, Immunology

References: 1 entry

Backus et al. 2011. Nat Chem Biol. 7(4):228-35. PMID: 21378984.


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References: 1 entry

Backus et al. 2011. Nat Chem Biol. 7(4):228-35. PMID: 21378984.


Add a reference

References: 1 entry

Backus et al. 2011. Nat Chem Biol. 7(4):228-35. PMID: 21378984.


Add a reference


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