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Anti-Fbxo7, Polyclonal [HLA3]

Invented by Dr Heike Laman at University of Cambridge

Info

Catalogue Number 151883
Applications IHC IP WB
Antigen/Gene or Protein Targets Fbxo7
Reactivity Human and Mouse
Relevance Recessive mutations in FBXO7/PARK15 cause an atypical EOPD. In certain cancers, the protein is highly expressed.

These cell lines all express Fbxo7: U2OS, SHSY5Y, HEK293, Jurkat, SKOV3, HeLa, Ba-F3, Nalm6, C33A, MEL, HSPCs, MEFs.
Host Rabbit
Immunogen aa 499-522 of human Fbxo7 synthetic peptide coupled to KLH
Molecular Weight (kDa) ~59/~70
Notes Staining Pattern: Nuclear and cytoplasmic, depending on stage of the cell cycle. May be aberrantly localised in pathological conditions.

This antibody is not available for licence, please refer to supplier information to find a source of the antibody.
Positive Control Any cultured cell line grown in FBS
Research Area Cell Cycle, Epigenetics & Nuclear Signalling

References: 6 entries

Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Europe PMC ID: 23933751

Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.

Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.

Europe PMC ID: 21652635

Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

Europe PMC ID: 16096642


Add a reference

References: 6 entries

Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Europe PMC ID: 23933751

Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.

Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.

Europe PMC ID: 21652635

Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.

Europe PMC ID: 16096642


Add a reference

References: 6 entries

Burchell et al. 2013. Nat Neurosci. 16(9):1257-65. PMID: 23933751.

The Parkinson's disease-linked proteins Fbxo7 and Parkin interact to mediate mitophagy.

Meziane el et al. 2011. J Cell Sci. 124(Pt 13):2175-86. PMID: 21652635.

Knockdown of Fbxo7 reveals its regulatory role in proliferation and differentiation of haematopoietic precursor cells.

Laman et al. 2005. EMBO J. 24(17):3104-16. PMID: 16096642.

Transforming activity of Fbxo7 is mediated specifically through regulation of cyclin D/cdk6.


Add a reference


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