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AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)

Invented by Dr Laurent Rigoreau from Cancer Research Technology
Invented at Cancer Research Technology

Info

Catalogue Number 151880
Antigen/Gene or Protein Targets Type 5 17-β-Hydroxysteroid Dehydrogenase (AKR1C3)
Type Inhibitor
Relevance CRT0093964 is a highly potent and selective inhibitor of the Type 5 17-β-Hydroxysteroid Dehydrogenase (AKR1C3).
On Target IC50 IC50 = 88 nM
Selectivity Displays >100-fold selectivity against AKR1C1, AKR1C2 and AKR1C4. Does not display any COX (cyclooxygenase) inhibition at 10 µM in whole blood assay.
Molecular Formula C15H20CIN3O2
lUPAC 4-(4-Chloro-phenyl)-piperazin-1-yl]-morpholin-4-yl-methanone
Molecular Weight (g/mol) 309.79
Research Area Cell Signaling & Signal Transduction, Metabolism, Neurobiology
Notes Referred to as A9 in Khanim et al., 2014.

References

There are 2 reference entries for this reagent.

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References: 2 entries

Khanim et al. 2014. Br J Cancer. 110(6):1506-16. PMID: 24569460.

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate.

Europe PMC ID: 24569460


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References: 2 entries

Khanim et al. 2014. Br J Cancer. 110(6):1506-16. PMID: 24569460.

Selective AKR1C3 inhibitors do not recapitulate the anti-leukaemic activities of the pan-AKR1C inhibitor medroxyprogesterone acetate.


Add a reference