AKR1C3 inhibitor CRT0036521 Small Molecule (Tool Compound)
Invented by Dr Laurent Rigoreau at Cancer Research Horizons
AKR1C3 inhibitor CRT0083914 Small Molecule (Tool Compound)
Invented by Dr Laurent Rigoreau from Cancer Research Horizons
Invented at Cancer Research Horizons
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- References (2)
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Info
| Catalogue Number | 151879 |
| Antigen/Gene or Protein Targets | AKR1C3 |
| Type | Inhibitor |
| Relevance | CRT0083914 is a novel non-carboxylate inhibitors of the aldo-ketoreductase enzyme AKR1C3, which is a target of interest in breast and prostate cancer and also some leukaemias. |
| On Target IC50 | IC50 = 94 nM |
| Selectivity | Displays much weaker inhibitory activity against AKR1C1, AKR1C2 and AKR1C4 (IC50 >30 µM). |
| Molecular Formula | C16H22N2O3S |
| lUPAC | 1-[4-(2-Methyl-piperidine-1-sulfonyl)-phenyl]-pyrrolidin-2-one |
| Molecular Weight (g/mol) | 322.43 |
| Research Area | Cell Signaling & Signal Transduction, Metabolism, Neurobiology |
| Notes | CRT0083914: a series of (piperidinosulfonamidophenyl)pyrrolidin-2-ones as potent (<100 nM) and isoform-selective non-carboxylate inhibitors of AKR1C3. Structure–activity relationships identified the sulfonamide was critical, and a crystal structure showed the 2-pyrrolidinone does not interact directly with residues in the oxyanion hole. Variations in the position, co-planarity or electronic nature of the pyrrolidinone ring severely diminished activity, as did altering the size or polarity of the piperidino ring. There was a broad correlation between the enzyme potencies of the compounds and their effectiveness at inhibiting AKR1C3 activity in cells. |
AKR1C3 inhibitor CRT0093964 Small Molecule (Tool Compound)
Invented by Dr Laurent Rigoreau at Cancer Research Horizons
Antigen/Gene or Protein Targets: Type 5 17-β-Hydroxysteroid Dehydrogenase (AKR1C3)
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References: 2 entries
Heinrich et al. 2013. Eur J Med Chem. 62:738-44. PMID: 23454516.
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.
Europe PMC ID: 23454516
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References: 2 entries
Heinrich et al. 2013. Eur J Med Chem. 62:738-44. PMID: 23454516.
Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3.
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